Cerebral sinus venous thrombosis in Swiss children |
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| Authors: | SEBASTIAN GRUNT KEVIN WINGEIER EDITH WEHRLI EUGEN BOLTSHAUSER ANDREA CAPONE JOEL FLUSS DANIELLE GUBSER‐MERCATI PIERRE‐YVES JEANNET ELMAR KELLER JEAN‐PIERRE MARCOZ THOMAS SCHMITT‐MECHELKE PETER WEBER MARKUS WEISSERT MAJA STEINLIN for the Swiss Neuropaediatric Stroke Registry |
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| Institution: | 1. Department of Neuropaediatrics, University Children’s Hospital, Inselspital, Berne, Switzerland;2. Institute of Psychology, University of Berne, Berne, Switzerland;3. Department of Neuropaediatrics, University Children’s Hospital, Zurich, Switzerland;4. Department of Neuropaediatrics, Children’s Hospital, Aarau, Switzerland;5. Neuropaediatrics, Paediatric Subspecialties Service, University Children’s Hospital, Geneva, Switzerland;6. Champreveyres 4, Neuchatel, Switzerland;7. Department of Neuropaediatrics, University Children’s Hospital, Lausanne, Switzerland;8. Department of Neuropaediatrics, Children’s Hospital, Chur, Switzerland;9. Rue de Lausanne 20, Sion, Switzerland;10. Department of Neuropaediatrics, Children’s Hospital, Luzern, Switzerland;11. Department of Neuropaediatrics, University Children’s Hospital, Basel, Switzerland;12. Department of Neuropaediatrics, Children’s Hospital, St Gallen, Switzerland. |
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| Abstract: | Aim To describe the characteristics of paediatric cerebral sinus venous thrombosis (CSVT) in Switzerland. Method Data on clinical features, neuroimaging, risk factors, and treatment were collected for all children in Switzerland younger than 16 years of age who had CSVT between January 2000 and December 2008. A follow‐up examination and a cognitive assessment were performed (mean follow‐up period 26mo). Differences between neonates and children (patients older than 28d) were assessed and predictors of outcome were determined. Results Twenty‐one neonates (14 males, seven females; mean age 9d, SD 8d) and 44 children (30 males, 14 females; mean age 8y 7mo, SD 4y 5mo) were reported. The incidence of paediatric CSVT in Switzerland was 0.558 per 100 000 per year. In neonates, the deep venous system was more often involved and parenchymal injuries were more common. The strongest predictor of poor outcome was neonatal age (odds ratio 17.8, 95% confidence interval 0.847–372.353). Most children showed global cognitive abilities within the normal range, but impairments in single cognitive subdomains were frequent. Interpretation Paediatric CSVT is rare. Its outcome is poor in neonates. Most children have good neurological outcomes, but some patients have individual neuropsychological impairments. |
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