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The Significance of Low Serum Pepsinogen Levels to Detect Stomach Cancer Associated with Extensive Chronic Gastritis in Japanese Subjects |
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| Authors: | Kazumasa Miki Masao Ichinose Norio Kawamura Masashi Matsushima Haron Bin Ahmad Masayoshi Kimura Junjiro Sano Takao Tashiro Nobuyuki Kakei Hiroshi Oka Chie Furihata Kenji Takahashi |
| Affiliation: | First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113;Department of Surgery, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia;Department of Molecular Oncology, Institute of Medical Science, University of Tokyo, 4-6-1 Shiroganedai, Minato-ku, Tokyo 108;Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo, 7-3-1 Kongo, Bunkyo-ku, Tokyo 113 |
| Abstract: | Serum pepsinogen levels were measured in 137 stomach cancer patients and compared with those of 288 normal cancer-free subjects. The serum pepsinogen levels of stomach cancer patients, especially pepsinogen I and the pepsinogen I/pepsinogen II ratio were significantly lower than those of normal controls and correlated well with the extent of chronic gastritis associated with the cancerous stomach. These results were in good accordance with the results of previous studies indicating that the cancer derived from the stomach where chronic gastritis/intestinal metaplasia is extensive. The high sensitivity and specificity of this non-invasive serum test to detect chronic gastritis suggested the possibility of its application to the mass screening of stomach cancer. |
| Keywords: | Pepsinogen Chronic gastritis Gastric cancer |