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| 脑室注射左旋硝基精氨酸甲酯对迟发性神经元坏死的影响 | |
| 引用本文： | 张敬军,陈青,江新泉. 脑室注射左旋硝基精氨酸甲酯对迟发性神经元坏死的影响[J]. 中国医院药学杂志, 2000, 20(4): 200-202 |
| 作者姓名： | 张敬军 陈青 江新泉 |
| 作者单位： | 1. 泰山医学院附属医院,山东,泰安,271000 2. 泰安卫生学校,山东,泰安,271000 |
| 摘 要： | 目的 :探讨一氧化氮合酶抑制剂左旋硝基精氨酸甲酯 (L NAME)在短暂性前脑缺血再灌注损伤中的作用。方法 :钳夹沙土鼠的双侧颈总动脉制造脑缺血模型 ,应用尼氏染色观察迟发性神经元坏死 (DND)的分布与数量。结果 :短暂性前脑缺血再灌注可导致海马CA1区锥体细胞DND ,一氧化氮合酶抑制剂L NAME明显地减少了DND。结论 :L NAME可能通过抑制神经原生型NOS对脑缺血起保护作用 |
| 关 键 词： | 脑缺血 海马 左旋硝基精氨酸甲酯 迟发性神经元坏死 |
Effect of intraventricular administration L-NAME on delayed neuronal death after recirculation following ischemia |
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| Zhang Jingjun,Chen Qing,Jiang Xinquan. Effect of intraventricular administration L-NAME on delayed neuronal death after recirculation following ischemia[J]. Chinese Journal of Hospital Pharmacy, 2000, 20(4): 200-202 | |
| Authors: | Zhang Jingjun Chen Qing Jiang Xinquan |
| Abstract: | OBJECTIVE:To observe the role of nitric oxide synthase inhibitor(L NAME) during the cerebral ischemia reperfusional injury.METHODS:Bilateral occlusion of common carotid arteries and the morphological changes of the neurons in gerbil hippocampal tissue slices were observed by light microscopy.RESULTS:The results showed that recirculation following ischemia induced delayed neuronal death(DND).L NAME reduced DND.CONCLUSIONS:It is possible that the role of endogenous NOS mediated DND is inhibited by L NAME. |
| Keywords: | cerebral ischemia hippocampus L-NAME delayed neuronal death |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |