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利培酮与氯丙嗪治疗精神分裂症对心电图的影响
引用本文:董秀凤,张玉胜,吴丽荣. 利培酮与氯丙嗪治疗精神分裂症对心电图的影响[J]. 药物流行病学杂志, 2003, 12(5): 241-242
作者姓名:董秀凤  张玉胜  吴丽荣
作者单位:滨州市人民医院,山东,滨州,256610
摘    要:
目的 :了解和比较利培酮与氯丙嗪对心电图的影响。方法 :对服用利培酮及氯丙嗪的精神分裂症患者分别定期心电图检查 ,时间为服药后 2、4周。结果 :利培酮组和氯丙嗪组出现异常分别为 11.5 %和 4 2 .5 % ,两者有显著性差异 (P <0 .0 5 )。结论 :利培酮对心电图影响明显低于氯丙嗪。

关 键 词:利培酮 氯丙嗪 药物治疗 精神分裂症 心电图 药物不良反应

The Effects of the Treatment of Patients with Risperidone and Chlorpromazine on Electrocardiogram(ECG)
Dong Xiufeng,Zhang Yusheng,Wu Lirong Binzhou City People''s Hospital,Shandong,P. R. China. The Effects of the Treatment of Patients with Risperidone and Chlorpromazine on Electrocardiogram(ECG)[J]. Chinese Journal of Pharmacoepidemiology, 2003, 12(5): 241-242
Authors:Dong Xiufeng  Zhang Yusheng  Wu Lirong Binzhou City People''s Hospital  Shandong  P. R. China
Affiliation:Dong Xiufeng,Zhang Yusheng,Wu Lirong Binzhou City People's Hospital,Shandong 256610,P. R. China
Abstract:
Objective: To study the effect of the treatment of patients with risperidone and chlorpromazine on ECG respectively. Methods: The patients were treated with risperidone and chlorpromazine, and ECG were regularly recorded in 2 to 4 weeks separately. Result: The abnormal rate was 11.5% in the risperidone group and that of chlorpromazine, 42.5% . The significant differences were found between the two groups ( P < 0.05 ). Conclusion: The effect of risperidone on the abnormal ECG was lower than that of chlorpromazine.
Keywords:Risperidone  Chlorpromazine  ECG  Adverse drug reaction
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