食管鳞状细胞癌组织ERK2蛋白的表达及意义

目的:研究细胞外信号调节激酶2(extracellular regulated kinase 2,ERK2)在食管鳞状细胞癌中的表达情况,探讨其在食管鳞状细胞癌发生、发展过程中的作用机制。方法:采用免疫组化(SP)法,检测ERK2蛋白在40例食管鳞状细胞癌组织及其配对癌周正常食管黏膜组织中的表达。结果:食管鳞状细胞癌组织中ERK2蛋白阳性表达率高于癌周正常食管黏膜组织(P<0.05)。ERK2蛋白的表达与年龄、性别、分期、癌组织的分化程度及淋巴结转移均无关(P>0.05)。结论:ERK2在食管鳞状细胞癌组织中呈高表达,提示它可能参与了食管鳞癌的恶性进展。

Expression of ERK2 protein in esophageal squamous cell carcinoma tissue and its significance

Objective： To investigate the expression of ERK2 protein in esophageal squamous cell carcinoma （ESCC） tissue and identify the relationships between ERK2 expression and develop- ment of ESCC. Method： The expression levels of ERK2 protein were examined by immunohisto- chemical SP method in 40 cases of normal esophageal mucosa and 40 cases of ESCC tissue. Re- sults： In normal mucosa and ESCC tissue, the expression rate of ERK2 protein in ESCC tissues was significantly high than normal mucosa（P 〈 0.05）. The expression of ERK2 was not related to the age, gender, tumor stage, differentiation degree and lymphatic metastasis of the patients （P 〉 0.05）. Conclusion ： The expression levels of ERK2 protein in ESCC were higher than normal mu- cosa, which shows that it may play an important role in the development of ESCC.