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| 玻璃体腔内注射Bevacizumab联合白内障手术治疗湿性年龄相关性黄斑变性(英文) | |
| 引用本文： | Jos M Ruiz-Moreno,Javier A Montero,Pedro Amat-Peral,Francisco L Lugo.玻璃体腔内注射Bevacizumab联合白内障手术治疗湿性年龄相关性黄斑变性(英文)[J].国际眼科杂志,2010,10(7):1245-1247. |
| 作者姓名： | Jos M Ruiz-Moreno Javier A Montero Pedro Amat-Peral Francisco L Lugo |
| 作者单位： | 1. 西班牙Castilla La Mancha大学阿利坎特医学院眼科;西班牙阿利坎特眼科研究所视网膜科 2. 西班牙阿利坎特眼科研究所视网膜科;西班牙Valladolid,Pío del Río Hortega大学附属医院眼科组 3. 西班牙阿利坎特眼科研究所视网膜科 |
| 摘 要： | 目的:探讨玻璃体腔内注射bevacizumab (Avastin)联合白内障手术预防脉络膜新生血管(choroidal neovascularization,CNV)的再次激活及年龄相关性黄斑变性(age-relatedmacular degeneration, AMD)。方法:对12例接受湿性年龄相关变性治疗的白内障患者给予透明角膜切口白内障超声乳化和人工晶状体植入手术,最后予以玻璃体腔内注射1.25mg bevacizumab (0.05mL)。主要评价指标:视力恢复、脉络膜新生血管的再次激活,及相干光断层成相术(OCT)对渗漏液体的评估。结果:患者最佳矫正视力(best-corrected visual acuity, BCVA)术后显著提高(脉络膜新生血管闭合后P<0.01,白内障发生后P=0.049,t检验)。白内障术后平均随访时间为11.8mo(标准差6.1,范围3 ～22mo),随访期内患者未出现脉络膜新生血管的再次激活及新的脉络膜新生血管病变。结论:在给予脉络膜新生血管及年龄相关性黄斑变性治疗的患者,白内障手术联合玻璃体腔内注射bevacizumab可预防脉络膜新生血管的再次激活。 |
| 关 键 词： | 年龄相关性黄斑变性 bevacizumab 白内障手术 脉络膜新生血管 |
Intravitreal bevacizumab and cataract surgery after wet age-related macular degeneration |
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| José M Ruiz-Moreno,Javier A Montero,Pedro Amat-Peral,Francisco L Lugo.Intravitreal bevacizumab and cataract surgery after wet age-related macular degeneration[J].International Journal of Ophthalmology,2010,10(7):1245-1247. | |
| Authors: | José M Ruiz-Moreno Javier A Montero Pedro Amat-Peral Francisco L Lugo |
| Institution: | José M Ruiz-Moreno1,2,Javier A Montero2,3,Pedro Amat-Peral2,Francisco L Lugo21Department of Ophthalmology,Albacete Medical School,Castilla La Mancha of Spain2Alicante Institute of Ophthalmology,VISSUM,Vitreo-Retinal Unit,Alicante,Spain3Pío del Río Hortega University Hospital,Ophthalmology Unit,Valladolid,Spain |
| Abstract: | AIM:To report the use of intravitreal bevacizumab associated with cataract surgery to prevent the re-activation of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD).METHODS:Twelve eyes from 12 patients who had been previously treated for wet AMD and presented cataracts were operated on by clear cornea phacoemulsification with intraocular lens implantation,and an intravitreal injection of 1.25mg (0.05mL) bevacizumab was performed by the end of the procedure.The results we... |
| Keywords: | age related macular degeneration chorio- capillaris atrophy intravitreous triamcinolone photodynamic therapy retinal pigment epithelium atrophy |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |