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Model for competition from self during passive immunization, with application to broadly neutralizing antibodies for HIV |
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| Authors: | Ali Tabei S M Li Ying Weigert Martin Dinner Aaron R |
| Affiliation: | a James Franck Institute, The University of Chicago, Chicago, IL 60637, United States b Department of Physics, The University of Chicago, Chicago, IL 60637, United States c Gwen Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, IL 60637, United States d Department of Pathology, The University of Chicago, Chicago, IL 60637, United States e Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL 60637, United States f Department of Chemistry, The University of Chicago, Chicago, IL 60637, United States |
| Abstract: | We propose a mathematical model to interpret observations concerning the behavior of broadly neutralizing antibodies for chronic HIV in vivo. The model enables us to identify a threshold antibody level that must be achieved to decrease the viral load effectively. Although this threshold has not been reached in existing passive immunization studies, it is within range of humoral immune responses, suggesting that therapeutic vaccines are feasible. In an appendix, we develop a model of passive immunization against influenza, and acute infection. |
| Keywords: | HIV Broadly neutralizing antibodies Passive immunization Mathematical model Self epitopes |
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