脑梗死患者血清中MMP-9表达水平的临床意义

目的通过动态分析脑梗死患者血清中基质金属蛋白酶-9（MMP-9）的表达水平，探讨患者血清MMP-9表达水平与脑梗死体积、神经功能缺损程度及预后的关系。方法应用酶联免疫吸附法（ELISA）检测120例脑梗死患者（梗死组）和100例健康者（对照组）的血清MMP-9的表达水平。采用统计学方法分析MMP-9水平与脑梗死的关系。结果梗死组血清MMP-9水平在第1、7、14天均明显高于对照组（P〈0．05），且血清MMP-9水平与脑梗死体积、神经功能缺损程度及患者的预后明显相关。可认为血清MMP-9高水平是判断脑梗死患者预后的独立危险因素。结论血清MMP-9水平升高是脑梗死的一个危险因素。

Clinical significance of serum MMP-9 levels in cerebral infarction patients

Objective To explore the relationships of serum MMP - 9 levels with the volume of cerebral infarction, degree of neurofunction impairment and prognosis by analyzing dynamic levels of serum MMP - 9 in patients with acute cerebral infarction. Methods ELISA was performed to detect the levels of MMP - 9 in 120 cases of cerebral infarction patients （ cerebral infarction group） and 100 cases of normal （control group）. Statistical methods were applied to analyze the relationships between the levels of MMP -9 with cerebral infarction. Results The levels of serum MMP -9 were significantly increased in cerebral infarction group compared to control group at day 1,7, 14. Moreover, the levels of serum MMP - 9 were significantly correlated with the volume of infarction, degree of neurofuction impairment and prognosis. Conclusion The high level of serum MMP - 9 may be considered as a risk factor of cerebral infartion.