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The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: Advancing Clinical Research in Subarachnoid Hemorrhage
Authors:Blessing N. R. Jaja  Daniel Attalla  R. Loch Macdonald  Tom A. Schweizer  Michael D. Cusimano  Nima Etminan  Daniel Hanggi  David Hasan  S. Claiborne Johnston  Peter Le Roux  Benjamin Lo  Ada Louffat-Olivares  Stephan Mayer  Andrew Molyneux  Adam Noble  Audrey Quinn  Thomas Schenk  Julian Spears  Jeffrey Singh  Michael Todd  James Torner  Ming Tseng  William van den Bergh  Mervyn D. I. Vergouwen  George K. C. Wong
Affiliation:1. Division of Neurosurgery, Department of Surgery, St. Michael’s Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael’s Hospital, University of Toronto, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
2. Department of Neurosurgery, Medical Faculty Heinrich Heine University, Düsseldorf, Germany
3. University of Iowa, Iowa City, IA, USA
4. University of California San Francisco, San Francisco, CA, USA
5. Jefferson University, Philadelphia, PA, USA
6. Columbia University, New York, NY, USA
7. Oxford University, Oxford, UK
8. Kings College London, London, UK
9. The General Infirmary, Leeds, UK
10. Friedrich-Alexander University, Erlangen, Germany
11. University of Toronto, University Health Network, Toronto, ON, Canada
12. Medicines and Healthcare Products Regulatory Agency, London, UK
13. University Medical Center Groningen, Groningen, The Netherlands
14. University Medical Center Utrecht, Utrecht, The Netherlands
15. Chinese University of Hong Kong, Hong Kong, China
Abstract:Researchers and other stakeholders continue to express concern about the failure of randomized clinical trials (RCT) in subarachnoid hemorrhage (SAH) to show efficacy of new treatments. Pooled data may be particularly useful to generate hypotheses about causes of poor outcomes and reasons for failure of RCT in SAH, and strategies to improve them. Investigators conducting SAH research collaborated to share data with the intent to develop a large repository of pooled individual patient data for exploratory analysis and testing of new hypotheses relevant to improved trial design and analysis in SAH. This repository currently contains information on 11,443 SAH patients from 14 clinical databases, of which 9 are datasets of recent RCTs and 5 are datasets of prospective observational studies and hospital registries. Most patients were managed in the last 15 years. Data validation and quality checks have been conducted and are satisfactory. Data is available on demographic, clinical, neuroimaging, and laboratory results and various outcome measures. We have compiled the largest known dataset of patients with SAH. The SAHIT repository may be an important resource for advancing clinical research in SAH and will benefit from contributions of additional datasets.
Keywords:
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