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| 盐酸氟桂利嗪预防性治疗偏头痛的疗效和安全性 | |
| 引用本文： | 于生元 董钊 李焰生 万琪 周盛年 乔向阳. 盐酸氟桂利嗪预防性治疗偏头痛的疗效和安全性[J]. 中国疼痛医学杂志, 2007, 13(4): 199-201 |
| 作者姓名： | 于生元 董钊 李焰生 万琪 周盛年 乔向阳 |
| 作者单位： | 1. 中国人民解放军总医院神经内科,北京,100853 2. 上海交通大学医学院附属仁济医院神经科 3. 江苏省人民医院神经内科 4. 山东大学齐鲁医院神经内科 5. 复旦大学附属华山医院神经内科 |
| 摘 要： | 目的：探讨盐酸氟桂利嗪预防性治疗偏头痛的有效性及安全性.方法：采用开放性研究,2120例偏头痛患者每日口服盐酸氟桂利嗪5～10 mg,治疗时间为12周,在治疗开始及4周末、8周末、12周末分别记录患者的头痛程度、频率、服药剂量、不良事件发生情况以及血压.结果：治疗后4周末、8周末及12周末与治疗前相比,头痛程度明显减轻（均P＜0.05）,频率明显减少（均P＜0.05）,盐酸氟桂利嗪用量亦明显减少（均P＜0.05）,未发现严重不良事件,治疗前后血压无明显变化（均P＞0.05）.结论：盐酸氟桂利嗪是一种安全有效的偏头痛预防性治疗药物. |
| 关 键 词： | 偏头痛 钙通道 盐酸氟桂利嗪 |
EFFICACY AND SAFETY OF FLUNARIZINE FOR PROPHYLAXIS TREATMENT ON MIGRAINE |
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| YU Sheng-Yuan,DONG Zhao,LI Yan-Sheng,Wan Qi,ZHOU Sheng-Nian,QIAO Xiang-Yang. EFFICACY AND SAFETY OF FLUNARIZINE FOR PROPHYLAXIS TREATMENT ON MIGRAINE[J]. Chinese Journal of Pain Medicine, 2007, 13(4): 199-201 | |
| Authors: | YU Sheng-Yuan DONG Zhao LI Yan-Sheng Wan Qi ZHOU Sheng-Nian QIAO Xiang-Yang |
| Affiliation: | Department of Neurology, Chinese PLA General Hospital, Beijing 100853 |
| Abstract: | Objective:To explore the efficacy and safety of flunarizine on migraine. Method: 2120 migraineurs took flunarizine (5~10 mg, qd) orally for 12 weeks.The intensity of headache (VAS),frequency of headache,dosage of flunarizine, adverse events and blood pressure were assessed before treatment and 4, 8, 12 weeks after treatment. Result:Significant difference existed among before treatment and 4, 8, 12 weeks after treatment in VAS, frequency of headache and dosage of flunarizine (all P<0.05). However, the blood pressure showed no significant difference among different time (all P>0.05).Severe adverse events were not found. Conclusion:Flunarizine is safe and effective for the prophylaxis treatment of migraine. |
| Keywords: | Migraine Calcium channel Flunarizine |
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