| 野马追总黄酮对实验性高脂血症大鼠脂代谢的影响 |
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| 引用本文： | 陈万一,秦剑,何海霞,李卿,王柯静,周远大.野马追总黄酮对实验性高脂血症大鼠脂代谢的影响[J].第三军医大学学报,2009,31(16). |
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| 作者姓名： | 陈万一 秦剑 何海霞 李卿 王柯静 周远大 |
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| 作者单位： | 1. 重庆医科大学附属第一医院临床药理研究室,重庆,400016
2. 重庆市中药研究院,重庆,400065 |
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| 基金项目： | 重庆市卫生局中医药科研项目 |
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| 摘 要： | 目的 探讨野马追总黄酮对实验性高脂血症大鼠脂代谢的影响及其降脂机制.方法 将60只SD大鼠随机分为空白对照组,高脂模型组,阳性药物(辛伐他汀片)对照组,野马追大、中、小剂量组,除空白对照组外,各组灌服高脂乳剂同时给予相应的药物60 d,观察野马追总黄酮对大鼠血脂水平,游离胆同醇(FCH)、游离脂肪酸(FFA)、脂蛋白脂酶(LPL)、肝脂酶(HL)、卵磷脂胆同醇酰基转移酶(LCAT)活性以及肝脏低密度脂蛋白受体(LDLR)基因表达的影响.结果 野马追总黄酮能显著降低高脂模型大鼠血浆总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白-胆固醇(LDL-C)水平,升高高密度脂蛋白.胆固醇(HDL-C)水平,提高LCAT、LPL和HL活性;RT-PCR实验显示高脂模型大鼠肝脏LDLR mR-NA表达降低,野马追总黄酮能显著上调高脂血症大鼠肝脏LDLR mRNA水平.结论 野马追总黄酮可能通过促进外周组织细胞中的胆固醇向肝脏转运,激活脂代谢相关酶的活性,促进肝脏LDLR mRNA的表达来调节脂质代谢紊乱.
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| 关 键 词： | 野马追 高脂血症 卵磷脂胆固醇酰基转移酶 低密度脂蛋白受体 逆转录聚合酶链反应 |
Effects of lindley eupatorium herb total flavonoid on blood lipid metabolism in experimental hyperlipidemic rats |
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| CHEN Wan-yi,QIN Jian,HE Hai-xia,LI Qing,WANG Ke-jing,ZHOU Yuan-da.Effects of lindley eupatorium herb total flavonoid on blood lipid metabolism in experimental hyperlipidemic rats[J].Acta Academiae Medicinae Militaris Tertiae,2009,31(16). |
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| Authors: | CHEN Wan-yi QIN Jian HE Hai-xia LI Qing WANG Ke-jing ZHOU Yuan-da |
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| Institution: | CHEN Wan-yi1,QIN Jian2,HE Hai-xia1,LI Qing2,WANG Ke-jing1,ZHOU Yuan-da1 (1Department of Clinical Pharmacology,First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,2Chongqing Academy of Chinese Materia Medica,Chongqing 400065,China) |
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| Abstract: | Objective To observe the effects of lindley eupatorium herb on blood lipid metabolism in SD rats and to explore the related mechanisms. Methods Sixty normal rats were randomly divided into six groups: control group,high-fatty model group,positive control group,lindley eupatorium herb high-dose,middle-dose and low-dose groups. Apart from the rats in the control group,all the rats in other groups were fed with high fat suspension and drugs respectively for 60 d. The effects of lindley eupatorium herb opuntia ... |
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| Keywords: | lindley eupatorium herb hyperlipidemia Lecithin cholesterol acyl transferase low density lipoprotein receptor RT-PCR |
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