| 穹窿海马伞切断鼠脑突触素动态变化及Morris水迷宫重复训练对其影响 |
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| 引用本文： | 曲巍,王孝文,王金平. 穹窿海马伞切断鼠脑突触素动态变化及Morris水迷宫重复训练对其影响[J]. 解剖科学进展, 2010, 16(2): 105-109 |
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| 作者姓名： | 曲巍 王孝文 王金平 |
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| 作者单位： | 潍坊医学院,人体解剖学教研室,山东,潍坊,261042 |
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| 摘 要： | 目的在Morris水迷宫(MWM)重复训练的过程中观察穹窿海马伞切断大鼠的突触素(SYN)动态变化探讨阿尔茨海默病(AD)的发病机制和MWM重复训练学习和记忆能力对AD的影响,为临床应用提供实验依据。方法采用wistar大鼠60只,随机分为对照组、模型组和实验组,建模后连续四周给予Morris水迷宫重复训练定位航行和探索训练,分别评定大鼠空间学习和记忆能力,后进行海马突触素(SYN)免疫组化染色和超微电镜观察并进行统计学处理。结果随着训练次数的增加,对照组、模型组、实验组逃逸时间均逐渐缩短,实验组短于模型组,长于对照组(P0.05),提示空间学习能力得到提高。对照组、模型组和实验组大鼠在靶象限活动时间(s)百分比无明显差异(P0.05),提示空间记忆能力无明显提高。SYN免疫组化实验组SYN表达高于模型组,弱于对照组。结论MWM重复训练增加海马SYN表达可能与提高穹窿海马伞切断大鼠空间学习能力有关。
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| 关 键 词： | Morris水迷宫 穹窿海马伞切断 突触素 Wistar大鼠 |
The dynamic changes of synaptophysin expression in hippocampus CA1 area of fimbria-fornix transacted rat and the effect of Morris water maze training |
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| QU Wei,WANG Xiao-wen,WANG Jin-ping. The dynamic changes of synaptophysin expression in hippocampus CA1 area of fimbria-fornix transacted rat and the effect of Morris water maze training[J]. Progress of Anatomical Sciences, 2010, 16(2): 105-109 |
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| Authors: | QU Wei WANG Xiao-wen WANG Jin-ping |
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| Affiliation: | Department of Human Anatomy;Weifang Medical College;Shandong Weifang 261042 China |
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| Abstract: | Objective To explore the dynamic changes of synaptophysin(SYN)expression in hippocampal CA1 area of fimbria-fornix transaction rat and the effect of Morris water maze training on the spacial memory to provide the experimental basis for clinical applications.Methods 60 wistar rats were randomly divided into control group,model(fimbria-fornix transaction)and experiment(Morris water maze training)groups.The expression of SYN was detected by immunohistochemical staining and ultrastructure was studied under tras... |
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| Keywords: | Morris water maze fimbria-fornix transaction synaptophysin Wistar rat |
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