Impact of intravesical hyaluronic acid and chondroitin sulfate on bladder pain syndrome/interstitial cystitis |
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| Authors: | Daniele Porru Fabio Leva Alberto Parmigiani Davide Barletta Dimitrios Choussos Barbara Gardella Maria Diletta Daccò Rossella Elena Nappi Massimo Allegri Carmine Tinelli Carlo Maria Bianchi Arsenio Spinillo Bruno Rovereto |
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| Affiliation: | Urology Department, IRCCS Policlinico San Matteo, Pavia, Italy. danieleporru@tin.it |
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| Abstract: | Introduction and hypothesis Intravesical instillations of hyaluronic acid (HA) and chondroitin sulfate (CS) may lead to regeneration of the damaged glycosaminoglycan layer in interstitial cystitis/bladder pain syndrome (IC/BPS). Methods Twenty-two patients with IC/BPS received intravesical instillations (40?ml) of sodium HA 1.6% and CS 2.0% in 0.9% saline solution (IALURIL?, IBSA) once weekly for 8?weeks, then once every 2?weeks for the next 6?months. Results The score for urgency was reduced from 6.5 to 3.6 (p?=?0.0001), with a reduction in pain scores from an average of 5.6 to 3.2 (p?=?0.0001). The average urine volume increased from 129.7 to 162?ml (p?p?p?p?Conclusion The treatment appeared to be effective and well tolerated in IC/BPS in this initial experience. |
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