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Evaluation of a new solution containg trehalose for twenty-hour canine lung preservation
Authors:Naohiro Kajiwara  Masahiko Taguchi  Hiroshi Saito  Shin Nakajima  Aeru Hayashi  Norihiko Kawate  Chimori Konaka  Hiromi Wada  Harubumi Kato
Affiliation:(1) Department of Surgery, Tokyo Medical College, 6-7-1 Nishi-shinjuku Shinjuku-ku, 160 Tokyo, Japan;(2) Department of Thoracic Surgery, Chest Disease Research Institute, Kyoto University, Kyoto, Japan
Abstract:
We examined the efficacy of two new preservation solutions containing trehalose-an extracellular type (ET-K) of solution and an intracellular type (IT-K) of solution — in relation to that of Euro-Collins (EC) solution in 20-h canine lung preservation. Canine lungs were flushed with one of the three solutions (n=5 for each solution) after pretreatment with PGE1 (20 mgrg/kg) and were stored for 20 h at 4°C. The left lungs were transplanted and evaluated to 6 h post transplant. In the ET-K group, the arterial oxygen tension after reperfusion was significantly higher than in the IT-K and EC groups. The pulmonary vascular resistance, wet/dry weight ratio, and histological evaluation of each transplanted lung in the ET-K group were also better than in the IT-K and EC groups. This indicates that ET-K solution is useful for 20-h preservation of canine lung grafts.
Keywords:Lung preservation, dog trehalose  Preservation, lung, trehalose  Trehalose, lung preservation
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