| 放射自显影法探讨针刺镇痛时脑内细胞水平~3H-r-氨基丁酸定位变化 |
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| 引用本文： | 朱寿,彭江骥.放射自显影法探讨针刺镇痛时脑内细胞水平~3H-r-氨基丁酸定位变化[J].针刺研究,1983(4). |
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| 作者姓名： | 朱寿 彭江骥 |
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| 作者单位： | 苏州医学院放射毒理教研室，苏州医学院放射毒理教研室 |
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| 摘 要： | <正> 文献中曾报道当给机体预先在脑室内注射r-氨基丁酸,对几种典型的惊厥剂都呈现出一定的对抗作用。这是因为r-氨基丁酸作为一个中性氨基酸,具有对中枢神经系统的抑制作用,表现在癫痫病人的大脑皮层中r-氨基丁酸含量呈现降低。因此,我们考虑探讨r-氨基丁酸与针刺镇痛的关系,从而为针麻作用原理的阐明,提供必要的依椐。本研究工作的目的,是要用冰冻微型放射自显影和组织固定微型放射自显影平行的观察机体在头面部电针镇痛时,脑内不同部位细胞水平的~3H-r-氨基丁酸的含量定位动态变化。因为微型放射自显影具有可以显示
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CHANGES IN LOCALIZATION OF ~3H-γ-AMINO BUTYRIC ACID IN BRAIN AT CELLULAR LEVEL IN THE PROCESS OF ACUPUNCTURE ANALGESIA BY MEANS OF MICROAUTORADIOGRAPHY |
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| Abstract: | The localization of the changes in ~2H-γ-amino butyric acid in the rats pallium and substantia medullaris of telencephalon, nucleus caudatus and corpus callosum, as well as pallium of aquaeductus cerebri induced by electroacupuncture were studied in parallel with the freezing microau- toradiographic and histo-fixative microautoradiographic methods. When the rats were subjected to electro-acupuncture, the tail-flickwas elevated and the both microautoradiographic intensity of ~3H-γ-amino butyric acid in pallium of telencephalon, nucleus caudatus and pallium of aquaeductus cerebri was increased. The results indicated that ~3H-γ-amino butyric acid in telencephalon and truncus encephali undergo profound depressive chan- ges in the process of acupuncture and emphasize that it may play an ex- treme important role in the effect of acupuncture analgesia. |
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