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人红细胞膜钠,钾-ATP酶活性及其在疾病时的变化
引用本文:杨渝珍,钱明,皇甫永穆,何美冬.人红细胞膜钠,钾-ATP酶活性及其在疾病时的变化[J].华中科技大学学报(医学版),1988(2).
作者姓名:杨渝珍  钱明  皇甫永穆  何美冬
作者单位:同济医科大学实验医学研究中心医学分子生物学研究室 (杨渝珍,钱明,皇甫永穆),同济医科大学附属同济医院中医科(何美冬)
摘    要:用酶学比色法测定了冠心病、风湿热、白血病、再生障碍性贫血等48例患者及28例正常人红细胞膜Na~+,K~+-ATPase的活性。结果表明除再生障碍性贫血外,其余患者红细胞膜Na~+,K~+-ATPase活性均不同程度下降,随着病情恢复,酶活性又呈增高趋势。乌巴因对Na~+,K~+-ATPase活性抑制百分数在各疾病组改变不明显。

关 键 词:腺苷三磷酸酶      红细胞膜  钠泵  乌巴因  血影细胞

Na+, K+-ATPase Activity of Human Erythrocyte Membrane and its Changes in Some Diseases
Yang Yuzhen,Qian Ming,Huangfu Yongmu.Na+, K+-ATPase Activity of Human Erythrocyte Membrane and its Changes in Some Diseases[J].Journal of Huazhong University of Science and Technology(Health Sciences),1988(2).
Authors:Yang Yuzhen  Qian Ming  Huangfu Yongmu
Institution:Yang Yuzhen,Qian Ming,Huangfu Yongmu Department of Medical Molecular Biologty,Research Center of Experimental Medicine,Tongji University,WuhanHe MeidongDepartment of Traditional Chinese Medicine,Tongji Hospital,Tongji Medical University,Wuhan
Abstract:We measured Na+, K+-ATPase activity of human erythrocyte membrane and compared Na+, K+-ATPase activity of healthy perscns(28 cases) with that of 48 patients with coronary heart disease, rheumatic fever, acute(or chronic) lympho-cytic and granulocytic leukemia, aplastic anemia, et al. The result indicated that Na+, K+-ATPase activity of erythrocyte membrane of all patients, excluding those with aplastic anemia, decreased to a certain extent, and increased gradually with recovery of health. No significant differences in the percentage of the inhibited enzymatic activity by oubain were observed between normal and various sickness groups.
Keywords:adenosine triphosphatase  sodium  potassium  erythrocyte membrane  sodium pump  oubain  ghosts
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