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Fatal thrombotic thrombocytopenic purpura as a rare complication following allogeneic stem cell transplantation |
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| Authors: | J. Chemnitz M. Fuchs W. Blau P. Hartmann C. Wickenhauser C. Scheid A. Schulz V. Diehl D. Söhngen |
| Affiliation: | I. Department of Medicine, University of Cologne, Joseph-Stelzmann-Str. 9, D-50924 K?ln, Germany e-mail: jens.chemnitz@uni-koeln.de Tel.: +49-221-4785044 Fax: +49-221-4786417, DE Department of Bone Marrow Transplantation and Hematology, Dr. Ottmar-Kohler-Str. 2, D-55743 Idar-Oberstein, Germany, DE Department of Pathology, University of Cologne, Joseph-Stelzmann-Str. 9, D-50924 K?ln, Germany, DE |
| Abstract: | Thrombotic thrombocytopenic purpura (TTP) is a rare disease which, together with hemolytic uremic syndrome, is subsumed under thrombotic microangiopathy. After stem cell transplantation (SCT), this syndrome represents a possibly fatal complication with a higher incidence in allogeneic SCT than in autologous SCT. Although plasmapheresis offers an encouraging treatment modality in classic TTP, this seems less effective in bone marrow transplant-associated microangiopathy. This is probably due to a different etiology. We present a case of transplant-associated TTP with a fatal outcome despite multiple courses of plasmapheresis. Received: 11 November 1999 / Accepted: 23 February 2000 |
| Keywords: | Stem cell transplantation Thrombotic thrombocytopenic purpura Plasmapheresis |
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