石棉肺及并发症的病理形态学观察

本文报告９例石棉肺的尸检及活检材料，结合文献对石棉肺的发生，胸膜斑的形成及肺内外肿瘤的发生进行了讨论。石棉肺及胸膜斑的形成与石棉纤维的机械性刺激有一定关系，肺癌的发生除与石棉纤维的机械性刺激有关外，还与石棉纤维表面吸附的强致癌物有关。这两种因素均可引起肺泡，细支气管上皮的增生，非典型性增生或癌变。

The pathomorphological observation of asbestosis and its complications

This paper presents the autopsy and biopsy results of nine instances of asbestosis, and by referring to the recent literatures, also discusses the occurrence of asbestosis, the formation of pleura spot, as well as the development of tumor in and out of the lung. The formation of asbestosis and pleura spot is related to the physical stimulation of asbestos fibers in some way; the development of lung cancer results from not only the stimulation of asbestos fibers,but also the cancerigenic substances absorbed on the surface of the fibers.The combination of these two factors can cause general or atypical proliferation and carcinomatous changes of pulmonary alveoli and bronchiolar epithelium.