经内镜下结肠置管灌肠治疗广泛型中度溃疡性结肠炎的应用研究

目的 评价经肠镜下置管灌肠对广泛结肠型中度溃疡性结肠炎的有效性以及安全性.方法 回顾性收集2016年3月至2020年2月于上海市第十人民医院确诊的中度溃疡性结肠炎患者142例,男性89例,女性53例,其中16例患者接受肠镜下置管术灌肠作为治疗组,经倾向值匹配(1:3)得到48例传统药物治疗患者作为对照组.治疗组给予肠镜...

Application of colonic transendoscopic enteral tubing in the treatment of extensive moderate ulcerative colitis

Objective To evaluate the efficacy and safety of colonic transendoscopic enteral tubing(TET)treatment for extensive moderate ulcerative colitis.Methods A total of 142 patients with ulcerative colitis in Shanghai Tenth People′s Hospital were collected retrospectively from March 2016 to February 2020,including 89 males and 53 females.Among them,16 patients received TET as the treatment group,and 48 patients treated with traditional drugs were selected as the control group after propensity matching(1∶3).The treatment group was given mesalazine enema(4.0 g,qn)through TET.The control group was treated with mesalazine anal enema(4.0 g,qn)and mesalazine enteric-coated tablets(1 g,tid).Before and 14 days after treatment,the Lichtiger clinical activity index,clinical score part of the modified Mayo score(pMayo),retention time after enema,serum C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),albumin(Alb)and fecal calprotectin(FCP)of the two groups were recorded and analyzed.Results In terms of clinical efficacy,the Lichtiger clinical activity index,pMayo score,serum CRP,ESR and FCP levels were significantly improved in both groups on the 14th day after treatment.The remission of Lichtiger index and pMayo score in the treatment group was significantly better than that in the control group(P<0.05).On the 14th day after treatment,the serum levels of CRP,ESR and FCP in the treatment group were significantly lower than those in the control group(P<0.05),but there was no significant difference in Alb level.In addition,the retention time of enema in the treatment group was significantly longer than that in the control group(P<0.0001).In terms of safety,there was no significant difference in the incidence of adverse reactions between the two groups(P=0.84).Conclusion TET is feasible,effective and safe in the treatment of extensive moderate ulcerative colitis,which is simple in clinical operation and worthy of popularization and application.