妊娠晚期孕妇B族链球菌感染对妊娠结局的影响

目的研究妊娠晚期孕妇B族链球菌(GBS)感染对妊娠结局的影响。方法选择2015年1月-2019年1月于新乡市中心医院门诊孕前检测并自然分娩的GBS阳性孕妇100例为GBS阳性组,同时选取自然分娩的GBS检测阴性的正常分娩妇女102名为GBS阴性组;分别检测分娩时羊水、胎盘及脐带血的GBS感染情况;记录母亲产后的临床症状;统计妊娠结局和新生儿感染状况。结果GBS阳性组孕妇羊水阳性率、胎盘阳性率、脐带血阳性率、宫内窘迫发生率分别为39.00%(39/100),29.00(29/100),40.00%(40/100),38.00%(38/100)均高于GBS阴性组,差异有统计学意义(P<0.05);GBS阳性组孕妇出现产后发热、产后出血和产褥感染、早产、胎膜早破和羊水污染率分别为8.00%(8/100),2.00%(2/100),6.00%(6/100),6.00%(6/100),9.00%(9/100),15.00%(15/100),与GBS阴性组比较,无统计学差异;GBS阳性组新生儿出现肺炎、败血症、化脓性脑膜炎、窒息、结膜炎率分别为8.00%(8/100),7.00%(7/100),4.00(4/100),5.00%(5/100)、2.00%(2/100),与GBS阴性组比较,无统计学差异。结论妊娠晚期GBS阳性孕妇羊水、胎盘及脐带血GBS阳性率会显著增加,尚未发现GBS感染对新生儿结局的影响。

Pregnancy outcomes of late trimester pregnancy women with group B Streptococcus infection

OBJECTIVE To explore the pregnancy outcomes of the late trimester pregnancy women with group B Streptococcus(GBS)infection.METHODS Totally 100 GBS-positive pregnant women who received progestational examination in the outpatient department of Xinxiang Central Hospital from Jan 2015 to Jan 2019 were assigned as the GBS-positive group,meanwhile,102 GBS-negative pregnant women who underwent vaginal delivery were set as the GBS-negative group.The prevalence of GBS infection in amniotic fluid,placenta and umbilical cord blood was detected at the delivery.The clinical symptoms of the puerpera were recorded after the delivery,and the pregnancy outcomes and incidence of neonatal infection were statistically analyzed.RESULTS The positive rates of GBS infection in amniotic fluid,placenta and umbilical cord blood and incidence of intrauterine distress of the GBS-positive group were respectively 39.00%(39/100),29.00(29/100),40.00%(40/100)and 38.00%(38/100),significantly higher than those of the GBS-negative group(P<0.05).The incidence rates of postpartum fever,postpartum hemorrhage,puerperal infection,premature delivery,premature rupture of membranes and contamination of amniotic fluid of the GBS-positive group were respectively 8.00%(8/100),2.00%(2/100),6.00%(6/100),6.00%(6/100),9.00%(9/100)and 15.00%(15/100),as compared with the GBS-negative group,there were no significant differences.The incidence rates of neonatal pneumonia,sepsis,suppurative meningitis,asphyxia and conjunctivitis of the GBS-positive group were respectively 8.00%(8/100),7.00%(7/100),4.00(4/100),5.00%(5/100)and 2.00%(2/100),as compared with the GBS-negative group,there were no significant differences.CONCLUSION The positive rates of GBS in amniotic fluid,placenta and umbilical cord blood may remarkably increased among the GBS-positive pregnancy women in late trimester of pregnancy.The GBS infection does not affect the neonatal outcomes.