氟比洛芬酯注射液用于烧伤患者镇痛的研究进展

烧伤疼痛一直是烧伤患者治疗及恢复过程中的一个难题,各种类型烧伤疼痛的性质和强度不同,给烧伤科临床医师对烧伤疼痛的判别和治疗带来了巨大挑战.阿片类药物作为临床治疗烧伤疼痛的首选药,镇痛效果好,但具有不良反应较多、耐药性、成瘾性等问题.氟比洛芬酯是临床上广泛使用的非甾体类抗炎药(NSAID),通过抑制前列腺素(PG)合成,...

Research progress of flurbiprofen axetil injection used for analgesia in burn patients

Burn pain has always been a difficult problem in the process of treatment and recovery of burn patients.Different types of burn pain have different nature and intensity.As the first choice in clinical treatment of burn pain,Opioids have good analgesic effect,but there are many adverse reactions,drug resistance,addiction and other problems.Flurbiprofen axetil is a widely used non-steroidal anti-inflammatory drug(NSAID)in clinic.It can inhibit the synthesis of prostaglandin(PG),decrease the sensitivity of spinal cord and central nervous system,reduce the pain impulse and exert the analgesic effect.Compared with other NSAID,flurbiprofen axetil injection can avoid local irritation of gastric mucosa and other adverse reactions,because it is a lipid microsphere carrier and has the characteristics of targeted treatment,fast onset and long duration of action,the application of preemptive analgesia and multi-mode analgesia in the treatment of burn pain can obviously improve the treatment effect of burn pain and provide a good treatment plan for all kinds of burn pain.