肌钙蛋白Ⅰ与CK-MB联合检测对急性心肌梗死的诊断价值

目的探讨肌钙蛋白I(cTnI)与CK-MB联合检测对急性心肌梗死(AM I)的临床诊断价值。方法采用罗氏电发光2010自动生化分析仪和日立7180生化分析仪,测定62例AM I患者、50例健康体检者血清的cTnI、肌酸激酶(CK)和CK-MB,并对结果进行统计学分析。结果AM I组血清cTnI、CK和CK-MB高于正常对照组(P<0.01)。cTnI与CK-MB联合检测阳性率为96.7%,高于前三者,且动态检测对早期AM I敏感性更高、阳性持续时间更长。结论肌钙蛋白I与CK-MB联合检测能提高早期急性心肌梗死的检出率,具有更宽的诊断时间窗。

Diagnostic value of cTnI and CK-MB combination detection in acute myocardial infarction

Objective To explore the clinical value of cardiac troponin I(cTnI) and creatine kinase MB(CK-MB) combination detection in the diagnosis of acute myocardial infarction(AMI).Methods Serum of 62 AMI patients and 50 healthy people were examined for cTnI,CK and CK-MB,performed with Rhodes and Hitachi autobiochemical analysis.The data were analyzed statistically.Results In AMI group,concentrations of cTnI,CK and CK-MB were significantly higher than those in control group(P<0.01).Sensitivity of combined markers(cTnI and CK-MB) was 96.7%,higher than cTnI,CK and CK-MB respectively.In AMI dynamic detection,combined markers were more sensitive in early stage of AMI and sustained positive for a longer time.Conclusion Combined markers of cTnT and CK-MB improve the detective rate of AMI in early stage and have a wider diagnostic time window.