Adjuvant endocrine therapy for perimenopausal women with early breast cancer |
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| Authors: | Olaf Ortmann Tanja Cufer J. Michael Dixon Nicolai Maass Paolo Marchetti Olivia Pagani Paolo Pronzato Vladimir Semiglazov Jean-Philippe Spano Eduard Vrdoljak Hans Wildiers |
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| Affiliation: | 1. Department of Obstetrics and Gynecology, University of Regensburg, Caritas-Hospital St. Josef, Landshuter Street 67, D-93053 Regensburg, Germany;2. Institute of Oncology, Ljubljana, Slovenia;3. Edinburgh Breast Unit, Western General Hospital, Edinburgh, Scotland, UK;4. University of Kiel, Kiel, Germany;5. Medical Oncology Department, Ospedale Sant''Andrea, Roma, Italy;6. Institute of Oncology of Southern Switzerland, Bellinzona, Switzerland;7. Instituto Nazionale per la Ricerca sul Cancro, Genova, Italy;8. Petrov Research Institute of Oncology, St. Petersburg, Russia;9. Department of Medical Oncology, Groupe Hospitalier Pitié-Salpétrière, Paris, France;10. Center of Oncology, Clinical Hospital Split, University of Split Medical School, Split, Croatia;11. Department of General Medical Oncology/Multidisciplinary Breast Centre, UH Gasthuisberg, Leuven, Belgium |
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| Abstract: | ![]()
Adjuvant treatment with aromatase inhibitors (AIs) improves outcomes in postmenopausal women with hormone-sensitive early breast cancer compared with tamoxifen. However, AIs should not be used in premenopausal women because they can paradoxically increase estrogen secretion and may therefore stimulate tumor progression. In perimenopausal women undergoing treatment for breast cancer, it can be difficult to determine true menopausal status because adjuvant chemotherapy, tamoxifen, and gonadotropin-releasing hormone analogues can induce transient (or permanent) ovarian suppression. How can one determine whether these women are truly postmenopausal and therefore candidates for AI therapy? A panel of experts in the field of endocrine therapy in breast cancer met in Dubrovnik, Croatia, on October 23, 2006, to discuss this clinical dilemma. This report summarizes the conclusions and recommendations that arose from this discussion. |
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