中国青年脑卒中发病危险因素的Meta分析

目的综合评价我国青年人群脑卒中发生的危险因素。方法应用Meta分析的方法对国内有关青年脑卒中发病危险因素的研究结果进行定量综合分析；运用Revman4．2进行异质性检验以及合并OR值和95％可信区间的计算。结果高血压、高血脂、吸烟和饮酒与青年脑卒中关系的OR值分别为6．60（4．48，9．06）、4．86（3．40，6．96）、2．20（1．56，3．10）和2．51（1．43，4．42），合并结果稳定性较好；家族史的OR值为5．91（3．48，10．02），但结果稳定性较差；肥胖与青年脑卒中关系的OR值为1．48（0．97，2．27），尚不能确定肥胖与青年脑卒中的关系。结论现有的有限证据表明，高血压、高血脂、吸烟、饮酒和家族史是中国青年人群脑卒中发病的危险因素。

Meta-analysis of Stroke Risk Factors among Chinese Youth

Objective To evaluate stroke risk factors in young population in China.Methods A comprehensive quantitative analysis was conducted,by Meta analysis method,on the domestic research results of stroke risk factors of Chinese young population.Using RevMan 4.2,test for heterogeneity was performed,pooled OR value and 95% confidence interval calculated.Results The pooled OR-values of the relationship of hypertension,hyperlipidemia,smoking,drinking to stroke were 6.60(4.48～9.06),4.86(3.40～6.96),2.20(1.56～3.10),2.51(1.43～4.42),respectively,and the combined result was stable.The OR-value of family history was 5.91(3.48～10.02),but the result was not stable.The OR-value of obesity was 1.48(0.97～2.27),so the relationship between obesity and stroke of youth was not determined.Conclusion The limited available evidence suggests that hypertension,hyperlipidemia,smoking,drinking and family history are the risk factors of stroke in Chinese young population.