中药蜈蚣药用历史沿革及其安全性探讨

目的：对中药蜈蚣的药用历史及其安全性进行探讨。方法：查阅相关文献资料，从古文献对蜈蚣药性认识、临床毒副作用、现代毒理研究及蜈蚣的安全使用等方面进行总结阐述。结果与结论：中药蜈蚣具有悠久的药用历史，古文献中多见其有毒的记载，现代毒理学研究表明，蜈蚣具有妊娠毒性、致过敏、肝肾毒性、神经系统毒性等多方面毒性作用。服用不当可引起过敏反应、肝、肾功能损害、神经系统损害及心肌受损、消化道疾患等不良反应，临床应用过程中应对其引起足够的重视。

Discussion on the medicinal history and security of the centipede

Objective： To discuss the medicinal history and security of the centipede. Methods： Consulted the relevant literature, summarized from the following aspects： the ancient understanding of the centipede＇s medicine properties, clinical toxic effects, modem toxicology studies, and the safe usage of the centipede, etc. Results and Conclusions： Centipede as traditional Chinese medicine has a long history. Its toxic recorded is more common in ancient literature. Modem toxicology studies show that the centipede has pregnant toxicity, anaphylactic reaction, liver and kidney toxicity, nervous system toxicity and many other toxic effects. Improper use can cause allergic reactions, liver and kidney damage, nervous system and myocardial damage, gastrointestinal diseases and other adverse reactions. It should be caused enough attention in the clinical application.