2型糖尿病患者血糖波动与中医证候的相关性

目的：探讨2型糖尿病患者血糖波动与中医证候的相关性。方法选取本院2010年1月－2013年12月病历资料完整并接受3 d动态血糖监测的2型糖尿病患者64例,辨证分为实证组和虚证组,实证组包括热盛津亏证、痰湿内阻证、血瘀脉络证,虚证组包括气阴两虚证、阴阳两虚证。观察患者血糖均值（MBG）、平均血糖波动幅度（MAGE）,并分析与中医证候的相关性。结果虚证组与实证组 MBG 比较差异无统计学意义（P＞0.05）,MAGE 比较差异有统计学意义（P＜0.05）。实证组各证型间 MAGE 比较差异无统计学意义（P＞0.05）；虚证组阴阳两虚证MAGE高于气阴两虚证,差异有统计学意义（P＜0.05）。结论2型糖尿病患者血糖波动与平均血糖无关,而与中医证候具有相关性,虚证类证候血糖波动性较大,阴阳两虚证血糖波动性最大。

Correlation of Blood Glucose Variability and TCM Syndromes in Type 2 Diabetic Patients

Objective To explore the correlation of blood glucose variability and TCM syndromes in type 2 diabetic patients. Methods A total of 64 type 2 diabetic patients from China-Japan Friendship Hospital during Jan. 2010 to Dec. 2013 with complete clinical data were measured by continuous glucose monitoring system （CGMs） for 3 days. Patients were divided into empirical group and deficiency group. The empirical group included heat excess and fluid deficiency syndrome, phlegm-dampness stagnation syndrome and blood stasis syndrome. The deficiency group included qi-yin deficiency syndrome and yin-yang deficiency syndrome. The mean blood glucose （MBG）, and mean amplitude of glycemic excursions （MAGE） were compared between the groups and types in each group, and the correlation with TCM syndrome types were analyzed. Results There was no significant difference in MBG between two groups （P〉0.05）. MAGE in deficiency group was higher than that in empirical group （P〈0.05）. No difference of MAGE existed among TCM syndrome types in empirical group （P〉0.05）, but in deficiency group, MAGE in yin-yang deficiency syndrome was higher than that in qi-yin deficiency syndrome （P〈0.05）. Conclusion Blood glucose variability has no correlation with MBG in type 2 diabetic patients. Glucose showed significant variability in deficiency group, and the most serious glucose variability was found in type of yin-yang deficiency syndrome.