子宫内膜癌组织中E-钙粘素与β-连环素的表达

目的:探讨子宫内膜癌组织中E-钙粘素和β-连环素的表达及意义。方法:采用免疫组织化学SP法检测58例子宫内膜癌、32例正常增生期子宫内膜和22例不典型增生子宫内膜石蜡包埋组织中E-钙粘素和β-连环素的表达。结果:在正常增生期子宫内膜、不典型增生子宫内膜和子宫内膜癌组织中E-钙粘素和β-连环素的异常表达率依次增高(P<0.05)。E-钙粘素的表达与肌层浸润、FIGO分期和淋巴结转移有关;而β-连环素的表达与病理分级、FIGO分期和淋巴结转移有关。结论:在子宫内膜癌发生发展过程中E-钙粘素和β-连环素异常表达起重要作用。

Expression of E-cadherin and beta-catenin in endometrial carcinoma tissue

Aim: To investigate the expression and significance of E-cadherin and beta-catenin in endometrial carcinoma tissue.Methods: Immunohistochemistry SP method was used to detect the expression of E-cadherin and beta GAAB2 catenin in 58 cases of endometrial carcinoma, 32 cases of normal endometrium at proliferative phase and 22 cases of atypical hyperplasia endometrium. Results: The aberrant expression rates of E-cadherin and beta-catenin increased significantly from normal endometrium at proliferative phase,atypical hyperplasia endometrium to endometrial carcinoma tissue(P<0.001, P<0.05).The aberrant expression rate of E-cadherin was significantly related to its myometrial invasion, FIGO stage and lymph node metastasis,while that of beta-catenin was related to its pathological grade, FIGO stage and lymph node metastasis.Conclusion: Aberrant expression of E-cadherin and beta-catenin may play an important role in oncogenesis, invasion and lymph node metastasis of endometrial carcinoma.