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| 原花青素对大鼠心肌缺血-再灌注损伤的保护作用 | |
| 引用本文： | 张国霞,武艳,韩冬梅,袁晓环. 原花青素对大鼠心肌缺血-再灌注损伤的保护作用[J]. 中国生化药物杂志, 2010, 31(3) |
| 作者姓名： | 张国霞 武艳 韩冬梅 袁晓环 |
| 作者单位： | 1. 黑龙江省富锦市中心医院,黑龙江,富锦,156100 2. 牡丹江医学院,黑龙江,牡丹江,157011 3. 牡丹江医学院,红旗医院,黑龙江,牡丹江,157011 |
| 基金项目： | 黑龙江省高等教育学会高等教育科学研究"十一五"规划课题 |
| 摘 要： | 目的探讨原花青素对大鼠心肌缺血-再灌注损伤引起的氧化应激损伤的保护作用。方法建立心肌缺血-再灌注模型。再灌注结束后采血,测定丙二醛(MDA)、超氧化物歧化酶(SOD)、天冬氨酸转氨酶(AST)、乳酸脱氢酶(LDH),测量心肌梗死面积。结果原花青素能明显降低血浆中MDA、AST和LDH的含量(P<0.05),提高SOD活性(P<0.05),减少心肌梗死面积(P<0.05)。结论原花青素对大鼠心肌缺血-再灌注损伤引起的氧化应激损伤的有保护作用。 |
| 关 键 词： | 原花青素 心肌缺血-再灌注损伤 氧化应激 |
Effects of proanthocyanidin on myocardial ischemia reperfusion injury in rats |
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| ZHANG Guo-xia,WU Yan,HAN Dong-mei,YUAN Xiao-huan. Effects of proanthocyanidin on myocardial ischemia reperfusion injury in rats[J]. Chinese Journal of Biochemical Pharmaceutics, 2010, 31(3) | |
| Authors: | ZHANG Guo-xia WU Yan HAN Dong-mei YUAN Xiao-huan |
| Abstract: | Purpose To investigate the protective effect of proanthocyanidin(PC) on oxidative stress injury induced by myocardial ischemia reperfusion(MIR) in rats.Methods MIR was carried out by ligation of left anterior descending coronary artery for 30 min followed by reperfusion for 120 min.Blood was collected at the end of reperfusion for detecting changes of malondialdehyde(MDA),superoxidedismutase(SOD),aspartateaminotransferase(AST),and lactatedehydrogenase(LDH).The myocardial infarct size was also estimated.Results PC pretreating decreased the contents of MDA,AST,LDH(P<0.05),and the myocardial infarct size(P<0.05),and increased the activity of SOD(P<0.05).Conclusion PC exerts protective effects on MIR injury. |
| Keywords: | proanthocyanidin myocardial ischemia reperfusion injury oxidative stress |
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