| 香烟烟雾可吸入微粒对大鼠支气管肺组织的氧化损伤研究 |
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| 引用本文： | 吴禹,周向东.香烟烟雾可吸入微粒对大鼠支气管肺组织的氧化损伤研究[J].临床肺科杂志,2006,11(6):703-704. |
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| 作者姓名： | 吴禹 周向东 |
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| 作者单位： | 400010,重庆医科大学附二院呼吸内科 |
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| 摘 要： | 目的探讨香烟烟雾可吸入微粒对支气管肺组织的氧化损伤作用。方法采集并分析香烟可吸入微粒后,染毒大鼠,观察肺组织病理形态的变化,测定肺泡灌洗液中白细胞总数和分类计数及肺匀浆中丙二醛(MDA)含量、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)活性。结果香烟组的病理改变以炎症为主,各观察指标与对照组比较有差异。结论香烟烟雾可吸入微粒对大鼠气道及肺组织的刺激引发炎性反应,而活性氧介导的炎症反应是其致炎作用机制之一。
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| 关 键 词： | 香烟烟雾 可吸入微粒 活性氧 |
| 收稿时间： | 03 27 2006 12:00AM |
| 修稿时间： | 2006年3月27日 |
Effect of inhalable particulate matter from tobacco smoke on airway oxidative damage in rats |
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| WU Yu,ZHOU Xiangdong.Effect of inhalable particulate matter from tobacco smoke on airway oxidative damage in rats[J].Journal of Clinical Pulmonary Medicine,2006,11(6):703-704. |
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| Authors: | WU Yu ZHOU Xiangdong |
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| Institution: | Department of Respiratory Medicine, The Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400010, China |
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| Abstract: | Objective To study effect of tobacco smoke on airway oxidative damage in rats.Methods Enironmental tobacco smoke were collected,analyzed and PM_(10)-treat model of rats were established.Lung tissue histopathology was observed.The counts of total leukocyte and neutrophils in bronchoalveoar lavage fluid(BALF) and superoxide dismutase(SOD),glutathion peroxidase(GSH-Px),malondiadehyde(MDA) in lung homogenate were measured.Results The counts of total leukocyte,macrophage and neutrophils in PM10-treat group were increased significantly than those in control group(P<0.05).The pathological changes of tobacco smoke group indicated that it can cause airway injury.Conclusion Tobacco smoke particles have ROS activity and cause lung inflammation. |
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| Keywords: | environmental tobacco smoke inhalable particulate ROS |
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