七氟烷和丙泊酚麻醉对老年肺癌患者术后认知功能的影响

目的：探讨七氟烷和丙泊酚麻醉对老年肺癌患者术后认知功能的影响。方法回顾性分析2010年1月~2013年12月本院收治的106例老年肺癌患者的临床资料,随机将所有患者分为观察组和对照组,每组各53例,分别于术前12 h,术后6 h、12 h、1 d、3 d、7 d对两组的患者进行MMSE评分,麻醉前、术后及术后1 d取静脉血测定血清中的S100β蛋白浓度浓度。结果所有患者均顺利完成手术,术中的各生命体征平稳,两组患者的者年龄、体重、疾病构成等差异无统计学意义（P〉0.05）,术前MMSE评分及术前S100β蛋白差异无统计学意义（P〉0.05）。术后两组的MMSE评分差异有统计学意义（P〈0.05）。结论七氟烷与丙泊酚均可提高老年患者全身麻醉术后早期认知功能。但七氟烷与丙泊酚相比,术后认知功能障碍的发生率较低,恢复更快。

Influence of anesthesia with sevoflurane or propofol on postoperative cognitive function in elder patients of lung cancer

Objective To compare the influence of sevoflurane and propfol anesthesia on the postoperative cognitive function in elder patients of lung cancer. Methods Retrospective analysis of clinical data in our hospital 106 cases of lung cancer of elderly patients from January 2010 to December 2013. All patients were randomly divided into 2 groups, Mini-mental state examination was conducted respectively at the time of 12 h preoperative, 6 h, 12 h, 1 d, 3 d, 7 d after the surgery. Blood samples were taken at before anesthesia, postoperative and 1 d after surgery, for the detection of serum concentration of S100β protein. Results All patients were successfully operated with stable vital signs of patients. In two groups, there was no significant difference of age, bodyweight, diseases （ P〉0.05）. There was no significant difference in preoperative MMSE grade and preoperative S100βprotein （P〉0.05）. MMSE grade after the two groups were statistically significant （P〈0.05）. Conclusion Propofol and sevoflurane can affect the early cognitive function in elderly patients after anesthesia and surgery. Compared with propofol, sevoflurane shows lower incidence rate of postoperative cognitive dysfunction and faster recovery.