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Immunohistochemical evidence for a substance P-containing trigeminovascular pathway to pial arteries in cats |
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| Authors: | Lee-Yuan Liu-Chen Marc R. Mayberg Michael A. Moskowitz |
| Affiliation: | 1. Stroke Research Laboratory, Neurosurgery Service, Massachusetts General Hospital,USA;2. Neurology Service, Massachusetts General Hospital, Dept. of Neurology, Harvard Medical School,USA;3. Dept of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, MA 02139 U.S.A. |
| Abstract: | Immunoreactive substance P-containing fibers were examined in large pial arteries from 3 cats 21–28 days following unilateral trigeminal ganglionectomy. The number and density of fibers decreased dramatically in arterior, middle and posterior cerebral arteries ipsilateral to the lesion. By contrast, no changes were present in basilar and other arteries supplying posterior fossa. These observations support the existence of a trigeminovascular substance P-containing pathway to large pial arteries supplying forebrain structures. |
| Keywords: | substance P trigeminal nerve circle of Willis immunohistochemistry innervation of cerebral arteries |
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