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Previous or Occult Hepatitis B Virus Infection in Hepatitis C Virus-Associated Hepatocellular Carcinoma Without Hepatic Fibrosis |
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| Authors: | Shoji Kubo Akihiro Tamori Kazuki Ohba Taichi Shuto Takatsugu Yamamoto Hiromu Tanaka Shuhei Nishiguchi Kenichi Wakasa Kazuhiro Hirohashi Hiroaki Kinoshita |
| Affiliation: | (1) Second Department of Surgery, Osaka City University Medical School, Osaka, Japan;(2) Third Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan;(3) Department of Pathology, Osaka City University Hospital, Osaka, Japan |
| Abstract: | We investigated the role of hepatitis B virus infection in development of hepatocellular carcinoma in hepatitis C virus-infected patients without hepatic fibrosis. Of 253 patients, 8 lacked hepatic fibrosis (group 1); group 2 included the remaining 245 patients. Clinicopathologic findings were compared between the groups. Hepatitis B x gene was sought in cancers and adjoining noncancerous liver. Group 1 showed better liver function parameters and milder active hepatitis than group 2. The proportion of patients with anti-hepatitis B virus antibody tended to be higher in group 1 than in group 2. The proportion of patients with hepatitis B x RNA in cancers was significantly higher in group 1 than in group 2. All group 1 patients had previous or occult hepatitis B virus infection. Previous or occult hepatitis B virus infection may be critical in development of hepatocellular carcinomas in hepatitis C virus-infected patients without hepatic fibrosis. |
| Keywords: | hepatocellular carcinoma hepatitis C virus hepatitis B virus hepatitis B x DNA hepatitis B x RNA hepatic fibrosis |
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