超氧化物歧化酶对窒息幼兔脑组织的保护作用

将３２只新西兰种幼兔随机分为对照组、室息组、窒息＋ＳＯＤ组。各组均于实验开始后２４小时心脏取血查ＬＰＯ、ＳＯＤ和ＧＳＨ－Ｐｘ、并取脑组织测脑水分含量。窒息组与对照组比较，血清ＬＰＯ、脑水分含量明显增高、（Ｐ均＜０．０１），血中ＳＯＤ、ＧＳＨ－ＰＸ活性明显降低（Ｐ均＜０．０１），窒息组ＬＰＯ与脑水分含量呈正相关关系。室息＋ＳＯＤ组与室息组比较，血清ＬＰＯ、脑水分含量明显减少（Ｐ均＜０．０１），ＧＳＨ－Ｐｘ活性增高（Ｐ＜０．０１）。提示ＯＦＲ参与了窒息所致脑损伤的病理过程，外源性ＳＯＤ可对室息幼兔脑组织起保护作用。

Protective effects of SOD cerebra injury of asphyxial young rabbits

hirty two young rabbits were divided into three groups: control ,asphyxial and asphyxiad + SOD,Blood was drawn from the hearts ofthese groups after 24hours,Oxygen free radical(OFR) in the bloodwas measured and H2O of the cerebral tissue was determined,Comparedwith the control group, LPO of the serum and H2 Oof the cerebral tis- sus significantly increased in the asphyxial group, while SODandGSH- px of the blood decreased significantly. And serum LPO was positivecorrelation with H2O of cerebral tissue in the asphyxial group,Com- pared with the asphyxiai group,serum LPO and H2O of the cerebral tissursignificantly decreased in the asphyxial + SOD group. while GSHPx sign- ificantly increased. The results of the experiment suggested that OFRcaused the brain to damage because of acute asphyxial and foreign SODeffectively protected the brain tissue of asphyxial young rabbits.