| 甘油单油酸酯液晶载体材料的体外毒性研究 |
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| 引用本文： | 周艳芳,彭新生.甘油单油酸酯液晶载体材料的体外毒性研究[J].中国医药导报,2010,7(10):22-24. |
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| 作者姓名： | 周艳芳 彭新生 |
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| 作者单位： | 1. 广东医学院病理生理学教研室,广东,东莞,523808
2. 广东医学院药剂学教研室,广东,东莞,523808 |
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| 基金项目： | 广东省东莞市科技局科研资助项目，广东省中医药管理局科研资助项目 |
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| 摘 要： | 目的：评价立方液晶载体材料甘油单油酸酯（glycerol monoolein,GMO）的细胞毒性。方法：体外培养大鼠皮肤成纤维细胞,以MTT法及琼脂覆盖法评价立方液晶对大鼠皮肤成纤维细胞的细胞毒性分级情况。结果：甘油单油酸酯对大鼠皮肤成纤维细胞的细胞活力无明显影响,毒性分级为0级。结论：甘油单油酸酯无潜在的细胞毒性,是一种生物相容性良好的载体材料。
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| 关 键 词： | 立方液晶 甘油单油酸酯 细胞毒性 |
In vitro cytotoxic study on fiquid crystalline material of glycerol monoolein |
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| ZHOU Yanfang,PENG Xinsheng.In vitro cytotoxic study on fiquid crystalline material of glycerol monoolein[J].China Medical Herald,2010,7(10):22-24. |
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| Authors: | ZHOU Yanfang PENG Xinsheng |
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| Institution: | 1.Department of Pathophysiology,Guangdong Medical College,Dongguan 523808,China; 2.Department of Pharmacy,Guangdong Medical College,Dongguan 523808,China) |
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| Abstract: | Objective：To evaluate the cytotoxicity of glycerol monoolein （GMO）. Methods：In vitro cultured rat skin flbroblast cells,MTT assay and agar overlay were used to evaluate toxicity grading of GMO on skin flbroblast cells. Results：GMO showed no effect on the activity of skin flbroblast cells. The cytotoxicity was graded 0 for the cultured rat epidermal cells. Conclusion：GMO has no potential cytotoxicity,which is suitable for the preparation on skin administration with excellent biocompatibility. |
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| Keywords: | Lipid based cubic liquid crystalline Glycerol monoolein Cytotoxicity |
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