N-三甲基壳聚糖对芦荟凝胶透皮吸收促进作用的体外研究

目的：研究季胺化程度为60％的N-三甲基壳聚糖（TMC60）对芦荟凝胶体外透皮吸收的影响。方法：分别制备含2％TMC60的芦荟凝胶（TMC60组），含2％氮酮的芦荟凝胶（阳性组），无促渗剂的芦荟凝胶（阴性组）。通过体外透皮扩散实验得到各组累积透过量Q9并求出稳态透皮速率Jo结果：TMC60组和阳性组的Q和J均显著大于阴性组（P〈0．05）；而TMC60组和阳性组相比差异无统计学意义（P〉0．05）。结论：2％TMC60与2％氮酮的体外透皮吸收促进效果相似，值得进一步研发。

Study on the Transdermal Penetration Enhancement of N-trimethyl Chitosan on Aloe Gels in vitro

Objective： To study the enhancement of N-trimethyl chitosan with degree of quaternization of 60% （TMC60） on the aloe gel in vitro. Method： Three different kinds of aloe gels, which was 2% TMC60 group,2% azonc group （positive control） and blank control group （without any enhancer） ,respectively,were prepared. The cumulative penetration （Q） and steady penetration rate （J） in vitro were used as the indices. Result： Significant difference was found on the Q and the J of TMC60 group and positive control group when compared with the blank control group （ P 〈 0. 05 ） , however no significant difference was found when TMC60 group was compared with the azone group （P 〉 0. 05 ）. Conclusion： 2% TMC60 is an efficient penetration enhancer with similar enhancement with 2% azone and valuable to he studied further.