门冬氨酸钾镁与氯化钾对非停跳冠状动脉旁路移植术围术期心律失常作用的比较

目的:观察非停跳冠状动脉旁路移植术(off-pump coronary artery bypass graft,OPCABG)中应用门冬氨酸钾镁(potassium magnesium aspartate,PMA)对围术期心律失常的影响。方法:将50例OPCABG患者随机分为门冬氨酸钾镁组(A组,n=25),氯化钾组(B组,n=25),在麻醉诱导后分别静脉持续滴入门冬氨酸钾镁及氯化钾溶液。2组术中及术后24h血浆钾浓度均维持在4.5～5.5mmol/L;分别记录术毕(T0)、术后4h(T1)、24h(T2)、48h(T3)、72h(T4)心律失常的发生率及血浆钾、镁离子水平。结果:A组与B组相比,术后心律失常较少,血浆镁离子浓度在T0、T1及T2时点明显高于B组,血浆钾离子浓度差异无统计学意义。结论:门冬氨酸钾镁可以安全应用于OPCABG,且可预防和治疗围术期的心律失常。

Effects of potassium magnesium aspartate on cardiac arrhythmia in off-pump coronary artery bypass graft

Objective： To investigate whether the intravenous infusion of potassium magnesium aspartate （PMA） can reduce the incidence of cardiac arrhythmia during and after off-pump coronary artery bypass graft （OPCABG） .Method： Fifty patients undergoing OPCABG were randomly divided into two groups group A（potassium magnesium aspartate, PMA, n = 25 ） received a potassium magnesium aspartate solution, group B （potassium chloride, n = 25） received potassium chloride, both solutions were administered continuously by central venous cannula during anesthesia to keep the serum potassium level between 4.5 and 5.5 mmol/L. The ineidenee of cardiac arrhythmia was noted at the end of surgery （TO）, 4 h（T1）, 24 h（T2）, 48 h（T3）, and 72 h（T4） postoperatively, serum magnesium and potassium levels were also measured. Result： Compared to group B, the incidence of eardiae arrhythmia was significantly lower in group A, the serum magnesium levels were significantly higher at T0, T1, T2 compared to group B.Conclusion：potassium magnesium aspartate can be used in OPCABG safely, the incidence of perioperative cardiac arrhythmia can be prevented and reduced significantly.