|
|||||
|
|
Aspirin resistance in patients with type II diabetes mellitus |
|
| Authors: | Eyyup Tasdemir Tayfur Toptas Cengiz Demir Ramazan Esen Murat Atmaca |
| Affiliation: | 1. Department of Internal Medicine, Van Training and Research Hospital,Van, Turkey;2. Department of Hematology, Van Training and Research Hospital,Van, Turkey;3. Department of Hematology, Yuzuncu Yil University,Van, Turkey;4. Department of Endocrinology, Yuzuncu Yil University,Van, Turkey |
| Abstract: | Background. Diabetic patients exhibit platelet hyperreactivity, which renders them resistant to antithrombotic treatments. We aimed to investigate the prevalence and predictors of aspirin resistance in diabetic patients. Material and methods. A total of 93 diabetic and 37 non-diabetic participants were included into the study. Aspirin resistance was measured with a whole-blood desktop platelet function analyzer (PFA-100) with an epinephrine agonist. Results. Altogether 41.9% patients with DM were aspirin non-responders. Aspirin resistance was observed in 43.2% of non-diabetic patients (p = 0.89). Presence of diabetes mellitus had no effect on aspirin response (RR 0.95 (95% CI 0.44–2.05), p = 0.89) in the whole study population. Hypercholesterolemia was the only predictor of aspirin resistance in multivariate analysis in diabetic patients (RR 3.09 (95% CI 1.17–8.16), p = 0.023). Conclusion. The prevalence of aspirin resistance is comparable in diabetic and non-diabetic patients. Hypercholesterolemia is the only independent predictor of aspirin resistance in diabetic patients. |
| Keywords: | Aspirin resistance diabetes mellitus PFA-100 |