辛伐他汀联合低分子肝素治疗不稳定型心绞痛效果的Meta分析

目的 系统评价辛伐他汀联合低分子肝素治疗不稳定型心绞痛的效果.方法 检索万方医学网、中国期刊全文数据库(CNKI)、重庆维普(VIP)、PubMed数据库中有关辛伐他汀联合低分子肝素治疗不稳定型心绞痛的文献,对纳入的15项随机对照试验(共1206名患者)进行Meta分析.结果 采用固定效应模型对两组总体有效率比较:x2 =2.62,综合RR=1.30(95％ CI:1.23 ～1.38);采用随机效应模型对两组治疗后发作次数比较:x2=1231.87,加权均数差=-2.68(-5.82,0.5)；采用随机效应模型对两组治疗后发作持续时间进行比较:x2=1231.87,加权均数差=-2.68(-5.82,0.5).结论 辛伐他汀联用低分子肝素能够提高不稳定型心绞痛的总体有效率,不能降低治疗后的发作次数,但能减少每次发作后持续的时间.

Meta-analysis for the curative effects of simvastatin combined with low molecular weight heparin in patient with unstable angina

Objective To assess the curative effects of simvastatin combine with low molecular weight heparin in patient with unstable angina. Methods The papers from China Academic Journal （ CNKI）, Chongqing VIP （VIP） ,PubMed database were retrieved by computer, 15 randomized controlled trials（ 1206 patients） were included for Meta-analysis. Results The overall efficiency of the two groups were compared by Fixed effects model： x^2 = 2. 62, Consolidated RR = 1.30 （95% CI：I. 23 - 1.38） ;the number of attacks after treatment of the two groups were compared by random effects model ：x^2= 1231.87, WMD = - 2.68 （ - 5.82,0.5 ） ; the duration time of attacks after treatment in both groups were compared by random effects model：x^2= 1231.87, weighted mean difference = -2.68 （ - 5.82,0.5）. Conclusion Simvastatin combine with low molecular weight heparin could improve the overall efficiency on patient with unstable angina, and could not reduce the number of attacks after treatment, but could reduce the duration time of attacks after the treatment.