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Return of fertility following discontinuation of an injectable contraceptive — Norethisterone oenanthate (NET EN) 200mg dose |
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| Authors: | National Programme of Research in Human Reproduction SK Banerjee R Baveja RV Bhatt A Chatterjee SD Choudhury B Coyaji AD Engineer MP Gogoi V Hingorani K Lal M Kochhar U Krishna P Misra FS Philips R Rajan PC Sen Gupta K Zaveri S Datey S Gupta S Mehta NC Saxena and BN Saxena |
| Institution: | 1Division of Reproductive Biology & Fertility Control Indian Council of Medical Research Ansari Nagar, New Delhi-110029, India 2R.G. Kar Medical College, Calcutta, India 3M.L.N. Medical College, Allahabad, India 4Baroda Medical College, Baroda, India 5Institute for Research in Reproduction, Bombay, India 6K.E.M. Hospital, Pune, India 7K.G. Medical College, Lucknow, India 8Medical College, Guwahati, India 9All India Institute of Medical Sciences, New Delhi, India 10Medical College, Jammu, India 11Kasturba Hospital, Delhi, India 12K.E.M. Hospital, Bombay, India 13S.P. Medical College, Bikaner, India 14Institute of Obst. & Gynaecology, Madras, India 15Medical College, Alleppy, India 16R.M.S.P. Hospital, Calcutta, India 17J.J. Hospital, Bombay, India 18Indian Council of Medical Research, New Delhi, India |
| Abstract: | The return of fertility following discontinuation of norethisterone oenanthate (NET EN) 200 mg injectable contraceptive after use for a minimum period of six months or more was studied in 69 women who discontinued the method for planning pregnancy. Former users of copper intra-uterine device (CuT 200) were enrolled as a control group. Another 161 women who had discontinued NET EN due to other reasons (e.g. amenorrhoea, excessive bleeding or personal reasons) were also studied for return of fertility after ensuring that they were not using any other method of contraception and were exposed to the risk of pregnancy. The subjects from both groups were followed for a period of one year. The cumulative conception rates at one year were 72.5 and 83.6 per 100 subjects for ex-NET EN and ex-CuT 200 users who had discontinued the method for planning pregnancy and this difference was not statistically significant (P > 0.05). The median time for conception for ex-NET EN users was 7.8 months as compared to 3.7 months in ex-CuT 200 users but the cumulative conception rates at the end of one year show that future return of fertility in NET EN users does not appear to be adversely affected. In 51 subjects who had discontinued NET EN due to amenorrhoea, the return of fertility was predictably slower and less. The return of fertility in subjects who discontinued NET EN for other reasons (e.g. excessive bleeding and other personal reasons) was similar to ex-NET EN and ex-CuT 200 users. |
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