| 异环磷酰胺的合成 |
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| 引用本文： | 汤磊,周训蓉,王建塔,李秀广.异环磷酰胺的合成[J].中国医药工业杂志,2006,37(8):513-514. |
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| 作者姓名： | 汤磊 周训蓉 王建塔 李秀广 |
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| 作者单位： | 1. 贵阳医学院药学院,贵州,贵阳,550004
2. 贵阳中医学院第二附属医院药剂科,贵州,贵阳,550003 |
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| 摘 要： | 氮杂环丙烷和3-氯丙醇经缩合、与三氯氧磷反应制得2-氯-3-（2-氯乙基）-1，3，2-氧氮磷杂环己烷-2-氧化物，再与2-氯乙胺盐酸盐缩合得到异环磷酰胺，总收率22．7％（以3-氯丙醇计）。
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| 关 键 词： | 异环磷酰胺 抗肿瘤药 合成 |
| 文章编号： | 1001-8255（2006）08-0513-02 |
| 收稿时间： | 2006-02-17 |
| 修稿时间： | 2006-02-17 |
Synthesis of Ifosfamide |
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| Authors: | TANG Lei ZHOU Xun-Rong WANG Jian-Ta LI Xiu-Guang |
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| Institution: | 1. School of Pharmacy, Guiyang Medical College, Guiyang 550004; 2. Dept. of Pharmacy, The Second Affiliating Hospital of Guiyang Traditional Medicine College, Guiyang 550003 |
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| Abstract: | Ifosfamide was synthesized from aziridine and 3-chloropropanol by condensation,reaction with POCl_3 to give 2-chloro-3-(2-chloroethyl)-1,3,2-oxazaphosphorine-2-oxide,which was subjected to condensation with 2- chloroethylamine in 22.7% overall yield(based on 3-chloropropanol). |
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| Keywords: | ifosfamide antitumor synthesis |
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