|
|||||
|
|
| 复方盐酸奈福泮萘普生钠缓释胶囊的制备和工艺考察 | |
| 引用本文： | 陈洪轩,陈寅生,马莉,游国叶. 复方盐酸奈福泮萘普生钠缓释胶囊的制备和工艺考察[J]. 中国药学杂志, 2011, 46(8): 605-609 |
| 作者姓名： | 陈洪轩 陈寅生 马莉 游国叶 |
| 作者单位： | 河南大学药物研究所;黄河科技学院;河南大学药学院;河南职工医学院; |
| 摘 要： | 目的 应用挤出滚圆法及流化床包衣制备盐酸奈福泮缓释微丸和萘普生钠肠溶缓释微丸，并对各自性质进行考察。 方法 采用国产挤出滚圆机制备盐酸奈福泮微丸和萘普生钠微丸，运用L9(34正交设计实验优化工艺条件；用微型流化床包衣设备，将盐酸奈福泮微丸包缓释衣、萘普生钠微丸包肠溶衣和缓释衣，分别考察两种微丸的粉体学性质及不同包衣增重微丸的体外释放实验。 结果 制得的盐酸奈福泮缓释微丸和萘普生钠肠溶缓释微丸圆整度好，大小均匀，体外释放也比较理想。结论 应用挤出滚圆机制备盐酸奈福泮微丸和萘普生钠微丸工艺简便，圆整度好，硬度适宜，收率较高；采用适当的包衣工艺，可制得质量良好的盐酸奈福泮缓释微丸和萘普生钠肠溶缓释微丸。 |
| 关 键 词： | 盐酸奈福泮 萘普生钠 挤出滚圆 微丸 流化床包衣 体外释放度 |
| 收稿时间： | 2011-11-11; |
Preparation and Technology Investigation of Compound Nefopam Hydrochloride and Naproxen Sodium Sustained-Release Capsule |
|
| CHEN Hong-xuan,,CHEN Yin-sheng,MA Li,,YOU Guo-ye. Preparation and Technology Investigation of Compound Nefopam Hydrochloride and Naproxen Sodium Sustained-Release Capsule[J]. Chinese Pharmaceutical Journal, 2011, 46(8): 605-609 | |
| Authors: | CHEN Hong-xuan CHEN Yin-sheng MA Li YOU Guo-ye |
| Affiliation: | CHEN Hong-xuan1,2,CHEN Yin-sheng3,MA Li3,4,YOU Guo-ye3(1.Institute of Chinese Materia Medica of Henan University,Kaifeng,475004,China,2.Technology of Yellow River institute,Zhengzhou 450063,3.Henan University,College of Pharmacy,4.Worker Medical School of Henan,Zhengzhou,451191,China) |
| Abstract: | OBJECTIVE To prepare nefopam hydrochloride(Nef) pellets and naproxen sodium(Npx-S) enteric-coated sustained-release pellets by the extrusion spheronization technology and the fluidized bed coating technology and to determine the pellets' properties.METHODS Nef pellets and Npx-S pellets were prepared using extrusion spheronization equipment.L9(34) orthogonal design was used to obtain optimal formulation.Using fluid bed coating equipment,the Nef pellets were coated with sustained-release coats,the Npx-S pelle... |
| Keywords: | nefopam hydrochloride naproxen sodium extrusion spheronization pellets fluidized bed coating technology dissolution in vitro |
| 本文献已被 CNKI 等数据库收录！ | |
| 点击此处可从《中国药学杂志》浏览原始摘要信息 | |
| 点击此处可从《中国药学杂志》下载免费的PDF全文 | |