| 内源性硫化氢在心血管系统中的作用与意义 |
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| 引用本文： | 张麟,鄢盛恺. 内源性硫化氢在心血管系统中的作用与意义[J]. 中国分子心脏病学杂志, 2008, 8(6): 366-370 |
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| 作者姓名： | 张麟 鄢盛恺 |
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| 作者单位： | 1. 中国协和医科大学中国医学科学院北京协和医院检验科,北京,100730
2. 卫生部中日友好医院检验科,北京,100029 |
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| 摘 要： | 内源性硫化氢是新近发现的继一氧化氮和一氧化碳的第三类气体信号分子，具有舒张血管、降低血压、抑制血管平滑肌细胞增殖、心肌负性肌力等多种生物学效应，并在动脉粥样硬化、高血斥、心肌缺血等多种心血管疾病的发生发展中具有重要的病理生理意义。本文仅就内源性硫化氢的生化特性，在心血管系统的生理作用、作用机制及病理生理意义进行综述。
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| 关 键 词： | 硫化氢 心血管系统 气体信号分子 氧化应激 |
The role and significance of endogenous hydrogen sulfide in the cardiovascular system |
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| ZHANG Lin,YAN Sheng-kai. The role and significance of endogenous hydrogen sulfide in the cardiovascular system[J]. Molecular Cardiology of China, 2008, 8(6): 366-370 |
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| Authors: | ZHANG Lin YAN Sheng-kai |
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| Affiliation: | ZHANG Lin , YAN Sheng-kai( 1.Department of Laboratory Medicine, PUMC Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China;2 Department of Laboratory Medicine, China-Japan Friendship Hospital, Ministry of Health, 100029, China) |
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| Abstract: | As the third gasotransmitter,hydrogen sulfide is a newly discovered gas signaling mole- cule,followed with nitrogen oxide and carbon monoxide.Endogenous hydrogen sulfide has a variety of bio- logical effects in the cardiovascular system,such as induces vasorelaxation,decreases blood pressure,inhib- its vascular smooth muscle cell proliferation,shows myocardial negative inotropic effects and plays patho- physiological role in numerous cardiovascular diseases,such as atherosclerosis,hypertension and cardiac is- chemia.The paper will elucidate the biochemical characteristics,the physiological function and the molecu- lar mechanisms of endogenous hydrogen sulfide in the cardiovascular system. |
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| Keywords: | Hydrogen sulfide Cardiovascular system Gasotransmitter Oxidative stress |
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