Importance of Myocardial Fibrosis in Functional Mitral Regurgitation: From Outcomes to Decision-Making |
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| Authors: | Bernardo B.C. Lopes Deborah H. Kwon Dipan J. Shah John R. Lesser Vinayak Bapat Maurice Enriquez-Sarano Paul Sorajja João L. Cavalcante |
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| Affiliation: | 1. Cardiovascular Imaging Research Center and Core Lab, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA;2. Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA;3. Valve Science Center, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA;4. Minneapolis Heart Institute, Abbott Northwestern Hospital, Minneapolis, Minnesota, USA;5. Houston Methodist Debakey Heart & Vascular Center, Houston, Texas, USA |
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| Abstract: | ![]()
Functional mitral regurgitation (FMR) is a common and complex valve disease, in which severity and risk stratification is still a conundrum. Although risk increases with FMR severity, it is modulated by subjacent left ventricular (LV) disease. The extent of LV remodeling and dysfunction is traditionally evaluated by echocardiography, but a growing body of evidence shows that myocardial fibrosis (MF) assessment by cardiac magnetic resonance (CMR) may complement risk stratification and inform treatment decisions. This review summarizes the current knowledge on the comprehensive evaluation that CMR can provide for patients with FMR, in particular for the assessment of MF and its potential impact in clinical decision-making. |
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| Keywords: | cardiac magnetic resonance functional mitral regurgitation myocardial fibrosis secondary mitral regurgitation CABG" },{" #name" :" keyword" ," $" :{" id" :" kwrd0035" }," $$" :[{" #name" :" text" ," _" :" coronary artery bypass grafting CMR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0045" }," $$" :[{" #name" :" text" ," _" :" cardiac magnetic resonance CRT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0055" }," $$" :[{" #name" :" text" ," _" :" cardiac resynchronization therapy EROA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0065" }," $$" :[{" #name" :" text" ," _" :" effective regurgitant orifice area FMR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0075" }," $$" :[{" #name" :" text" ," _" :" functional mitral regurgitation LGE" },{" #name" :" keyword" ," $" :{" id" :" kwrd0085" }," $$" :[{" #name" :" text" ," _" :" late gadolinium enhancement LV" },{" #name" :" keyword" ," $" :{" id" :" kwrd0095" }," $$" :[{" #name" :" text" ," _" :" left ventricle LVEF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0105" }," $$" :[{" #name" :" text" ," _" :" left ventricle ejection fraction MF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0115" }," $$" :[{" #name" :" text" ," _" :" myocardial fibrosis MI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0125" }," $$" :[{" #name" :" text" ," _" :" myocardial infarction MR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0135" }," $$" :[{" #name" :" text" ," _" :" mitral regurgitation PISA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0145" }," $$" :[{" #name" :" text" ," _" :" proximal isovelocity surface area PM" },{" #name" :" keyword" ," $" :{" id" :" kwrd0155" }," $$" :[{" #name" :" text" ," _" :" papillary muscle RegFrac" },{" #name" :" keyword" ," $" :{" id" :" kwrd0165" }," $$" :[{" #name" :" text" ," _" :" regurgitant fraction TMVr" },{" #name" :" keyword" ," $" :{" id" :" kwrd0175" }," $$" :[{" #name" :" text" ," _" :" transcatheter mitral valve repair |
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