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ER stress abrogates the immunosuppressive effect of IL-10 on human macrophages through inhibition of STAT3 activation
Authors:Hansen  Ivo S.  Schoonejans  Josca M.  Sritharan  Lathees  van Burgsteden  Johan A.  Ambarus  Carmen A.  Baeten  Dominique L. P.  den Dunnen  Jeroen
Affiliation:1.Amsterdam Rheumatology and Immunology Center, Location Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
;2.Department of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
;
Abstract:Inflammation Research - To determine whether ER stress affects the inhibitory pathways of the human immune system, particularly the immunosuppressive effect of IL-10 on macrophages. In vitro...
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