慢性阻塞性肺疾病与脑梗死相关性研究

目的探讨慢性阻塞性肺疾病(CPOD)并发脑梗死的相关因素。方法选取2012-2014年间201例慢性阻塞性肺病(COPD)患者,均行头颅MRI或CT检查,血小板,血红蛋白,D-二聚体,纤维蛋白原,胆固醇,甘油三酯,ESR,CRP,血气分析,肺功能检查,以COPD合并脑梗死的患者为观察组(76例),COPD非合并脑梗死的患者为对照组(125例)。结果观察组与对照组相比,D-二聚体分别为(1035.23±304.21)和(362.4±256.01)μg/L,血红蛋白分别为(178.43±25.88)和(143.67±35.41)g/L,Pa O2分别为(68.36±25.34)和(82.71±31.25)mm Hg,Pa CO2分别为(58.68±10.53)和(35.41±4.13)mm Hg,肺功能检查重度阻塞性通气功能障碍比例分别为33.3%和25.1%,纤维蛋白原分别为(3.68±0.36)和(2.56±0.42)g/L,两组间比较差异有统计学意义(P0.01)。结论慢性阻塞性肺疾病是引起脑梗死的高危因素,这可能与慢性阻塞性肺病患者长期慢性缺氧,二氧化碳潴留,D-二聚体,血红蛋白及纤维蛋白原升高有关。

Correlation between chronic obstructive pulmonary disease and cerebral infarction

Objective To investigate the possible mechanism of CPOD patients complicated with brain in-farction. Methods 201 COPD patients were selected at random, each of which were underwent brain MRI or CT, platelet, hemoglobin, D-dimer, cholesterol, triglyceride, ESR, CRP, blood gas analysis, and pulmonary function tests. 76 of them complicated with cerebral infarction were taken as the observation group. Results The level of D-dimer was （1035. 23 ± 304. 21） and （362. 4 ± 256. 01）μg/L, the level of hemoglobin was （178. 43 ± 25. 88） and （143. 67 ± 35. 41）g/L, the level of PaCO2 was （68. 36 ± 25. 34） and （82. 71 ± 31. 25） mmHg, and the level of PaCO2 was （58. 68 ± 10. 53） and （35. 41 ± 4. 13）mmHg respectively in the observation group and the control group. The ratio of severe obstructive ventilation dysfunction was 33. 3% and 25. 1% respectively in the observation group＆amp;nbsp;and the control group. The content of fibrinogen was （3. 68 ± 0. 36） and （2. 56 ± 0. 42） g/L respectively in the ob-servation group and the control group. Conclusion Chronic obstructive pulmonary disease is the high-risk factor causing cerebral infraction, which may be related to long time chronic hypoxia, hypercapnia, and high level of D-di-mer and hemoglobin.