| 丹参注射液对人肝微粒体酶CYP2C9,CYP2C19,CYP2D6体外抑制作用的研究 |
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| 引用本文： | 叶娜,万丽,杨秋楠,李小彬,王海蓉,肖昌兵. 丹参注射液对人肝微粒体酶CYP2C9,CYP2C19,CYP2D6体外抑制作用的研究[J]. 现代药物与临床, 2014, 37(6): 502-506 |
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| 作者姓名： | 叶娜 万丽 杨秋楠 李小彬 王海蓉 肖昌兵 |
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| 作者单位： | 成都中医药大学药学院, 中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 四川 成都 611137;成都中医药大学药学院, 中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 四川 成都 611137;成都中医药大学药学院, 中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 四川 成都 611137;成都中医药大学药学院, 中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 四川 成都 611137;成都中医药大学药学院, 中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 四川 成都 611137;成都中医药大学药学院, 中药材标准化教育部重点实验室, 中药资源系统研究与开发利用省部共建国家重点实验室培育基地, 四川 成都 611137 |
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| 摘 要： | 目的 评价丹参注射液在体外对人肝微粒体酶CYP2C9、CYP2C19、CYP2D6活性的影响。方法 将丹参注射液与CYP450酶3种亚型(CYP2C9、CYP2C19、CYP2D6)的特异性探针底物甲苯磺丁脲、奥美拉唑、右美沙芬与大鼠肝微粒体进行孵育,采用LC-MS/MS法测定对应3种代谢产物4-羟基甲苯磺丁脲、5-羟基奥美拉唑、右啡烷的浓度,求算出IC50。结果 丹参注射液对CYP2C9、CYP2C19和CYP2D6的IC50值均>50 μg/mL。结论 丹参注射液对人肝微粒体酶CYP2C9、CYP2C19、CYP2D6没有抑制作用。
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| 关 键 词： | 细胞色素P450酶 丹参注射液 人肝微粒体 抑制 |
| 收稿时间： | 2014-09-03 |
In vitro inhibition of Danshen Injection on human liver cytochrome P450 enzyme CYP2C9, CYP2C19, CYP2D6 |
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| YE N,WAN Li,YANG Qiu-nan,LI Xiao-bin,WANG Hai-rong and XIAO Chang-bing. In vitro inhibition of Danshen Injection on human liver cytochrome P450 enzyme CYP2C9, CYP2C19, CYP2D6[J]. Drugs & Clinic, 2014, 37(6): 502-506 |
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| Authors: | YE N WAN Li YANG Qiu-nan LI Xiao-bin WANG Hai-rong XIAO Chang-bing |
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| Affiliation: | The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China |
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| Abstract: | |
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| Keywords: | cytochrome P450 enzyme Danshen Injection human liver microsome inhibition |
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