Post-menopausal bleeding: a rare presentation of metastatic uveal melanoma |
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Authors: | Michael A Coutts Nicola J Borthwick John L Hungerford Ian A Cree |
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Institution: | (1) Cellular Pathology, Preston Hall Hospital, Maidstone and Tunbridge Wells NHS Trust, Kent;(2) Department of Pathology, Institute of Ophthalmology, University College London, Bath Street, London;(3) Ocular Oncology Service, Moorfields Eye Hospital, City Road, London;(4) Translational Oncology Research Centre, Queen Alexandra Hospital, Portsmouth, England |
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Abstract: | Uveal melanoma differs from cutaneous melanoma in many ways, including its pattern of metastasis, and exhibits latency with
clinical evidence of metastasis sometimes appearing many years after primary diagnosis. Most patients develop metastasis within
the liver, but some may present with metastasis to other sites. We report a case of uveal melanoma that presented with post-menopausal
bleeding due to metastasis. Further investigation revealed widespread metastatic disease and the patient was not fit for chemotherapy.
She died two months after presentation: autopsy revealed metastases in many sites, including the uterus, right ovarian fibroma,
kidney, mesentery, liver, lung, thyroid, bone marrow and skin. The immediate cause of death was cardiac tamponade due to a
malignant effusion secondary to cardiac metastasis. This case illustrates the widespread metastatic potential of uveal melanoma
and highlights the potential for unusual presentation of metastatic disease from this eye tumor.(Pathology Oncology Research
Vol 12, No 3, 184–187) |
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Keywords: | melanoma eye uveal endometrium post-menopausal bleeding metastasis |
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