米氮平与米安色林治疗老年抑郁症的对照研究

目的:比较米氮平与米安色林治疗老年抑郁症的疗效与安全性。方法:68例老年抑郁症患者随机分为两组,其中米氮平组35例,米安色林组33例,观察期为8周,使用HAMD和TESS量表于治疗前、治疗后1、2、4、6、8周评估两组的疗效和安全性。结果:经过8周治疗,有效率和显效率米氮平组分别为91.4%和74.3%%,米安色林组分别为87.9%和72.7%,组间差异不显著(P>0.05)。两组治疗后HAMD评分下降均有显著性(P<0.01),两组间HAMD评分减分率差异无显著性(P>0.05)。米氮平组不良反应有嗜睡、头昏、食欲增加、体重增加等,米安色林组常见不良反应为头昏、恶心、嗜睡等,两组的不良反应均较轻微。结论:两药都是治疗老年抑郁症有效而安全的药物。

Controlled Study of Mirtazapine and Mianserine in the Treatment of Senile Depression

Objective:To compare the efficacy and safety of mirtazapine and mianserine in the treatment of senile depression. Methods:68 senile depressive patients were randomly divided into two groups: 35 in mirtazapine group, 33 in mianserine group. The period of observation was 8 weeks, Efficacy and safety were assessed with HAMD and TESS scales at baseline, week 1, 2, 4, 6 and 8 after treatment. Results: After 8 weeks of treatment, the response rate and significant response rate were respectively 91.4% and 74.3% in mirtazapine group, 87.9% and 72.7% in mianserine group, the difference between groups were not statistically significant. The reduction of HAMD scores after treatment in both group were statistically significant (P<0.01). The reduction of HAMD scores between the two groups were not statistically significant (P> 0.05). The common side effectives of mirtazapine were drowsiness, dizziness, increased appetite and weight gain; The common side reactions of mianserine were dizziness, nausea, drowsiness. All the side effects were mild. Conclusions:Mirtazapine and mianserine are equally effective and safe in treating senile depression.