6种光固化复合树脂吸水性、溶解性和单体释放量的比较

目的：比较6种光固化复合树脂吸水值、溶解值和单体释放量，探讨其影响因素，并阐明其与材料组成成分和浸泡液的关系。方法：根据ISO 4049-2009标准，测量6种复合树脂FiltekTM Z250（Z250）、FiltekTM Z350 XT（Z350）、Aelite LS Posterior（ALS）、CLEARFIL MAJESTY Posterior（CMP）、Neofil Nano（NN）和Tetric N-Ceram（TNC）的吸水值和溶解值，并将6种树脂试件浸泡于75%乙醇溶液中，在不同时间点（24h、7d、1个月和3个月）终止浸泡，利用液相色谱质谱仪测量各时间段内浸泡液中Bis-GMA和TEGDMA单体释放量。结果：6种光固化复合树脂的吸水值由小到大依次为ALS < CMP < TNC≈Z250 < NN < Z350，组间比较差异有统计学意义（P<0.05）；溶解值由小到大依次为Z350 < NN≈ALS≈CMP≈Z250 < TNC，组间比较差异有统计学意义（P<0.05）。Bis-GMA释放量，树脂随着浸泡时间延长释放量缓慢增加（P<0.05），其中ALS和CMP 3个月时释放量变小（P<0.05），3个月时释放量由大到小依次为NN > TNC > Z250 > Z350 > ALS > CMP（P<0.05）；TEGDMA释放量，NN和TNC未检出，另外4种树脂的TEGDMA释放量随着时间延长缓慢增加（P<0.05），其中CMP 3个月时释放量变小（P<0.05），3个月时释放量由大到小依次为ALS > CMP > Z250 > Z350（P<0.05）。结论：不同复合树脂的吸水性、溶解性及单体释放量不同，且与有机基质组成成分和浸泡液有关。

Comparison of water absorption,solubility and monomer release of six kinds of light-curing composite resins

Objective:To compare the water absorption values,solubility values and monomer release amounts of six kinds of light curing composite resins and explore the influencing factors,and to elucidate their relationships with the material compositions and the immersing solvent.Methods:The water absorption and solubility values of six kinds of composite resins,including FiltekTM Z250 (Z250),FiltekTM Z350 XT (Z350),Aelite LS Posterior (ALS),CLEARFIL MAJESTY Posterior (CMP),Neofil Nano (NN),and Tetric N-Ceram (TNC),were measured according to ISO 4049-2009.The concentrations of eluted Bis-GMA and TEGDMA were tested by liquid chromatography/mass spectrometry after the specimens were immersed in 75％ ethanol solution for different time (24 h,7 d,1 month,and 3 months).Results:The water absorption values of six kinds of composite resins were in ascending order of ALS ＜CMP ＜TNC ≈Z250 ＜NN ＜Z350,there were significant differences between groups (P＜0.05);the solubility values were Z350 ＜NN≈ALS≈CMP≈Z250 ＜TNC,there were significant differences between groups (P＜0.05).The release amounts of Bis-GMA were increased slowly with the prolongation of time (P＜0.05),while the values of ALS and CMP at 3 months were decreased (P＜0.05);the descending order ofBis-GMA release amounts at 3 months was NN＞ TNC＞ Z250＞ Z350＞ ALS＞ CMP (P＜0.05).The released TEGDMA was not found in NN and TNC.The release amounts of TEGDMA of the other four resins were increased slowly with the prolongation of time (P＜0.05),and the release amount of CMP at 3 months was decreased (P＜0.05);the order of amount at 3 months was ALS＞ CMP＞ Z250＞ Z350 (P＜0.05).Conclusion:The water absorption values,solubility values and monomer release amounts of different composite resins are different,and they are related to their organic matrix compositions and the immersing solvent.