Induction of p53 protein by carbon-ion and proton beam irradiation in two close human lymphoblastoid cell lines with different p53 status |
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| Authors: | Fukushima S Ozeki S Tang J Koizumi M Matsumura S Inoue T Yamazaki H Murayama S Hatanaka K Ejiri H Kasai K |
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| Affiliation: | OSAKA UNIV,GENOME INFORMAT RES CTR,SUITA,OSAKA 565,JAPAN. OSAKA UNIV,SCH DENT,DEPT ORAL & MAXILLOFACIAL RADIOL,SUITA,OSAKA 565,JAPAN. HOSP UNIV PENN,UNIV PENN,SCH MED,DEPT RADIAT ONCOL,PHILADELPHIA,PA 19104. NATL CANC CTR,DIV RADIAT THERAPY,CHUO KU,TOKYO 104,JAPAN. OSAKA UNIV,NUCL PHYS RES CTR,IBARAKI,OSAKA 567,JAPAN. NATL INST RADIOL SCI,INAGE KU,CHIBA 263,JAPAN. |
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| Abstract: | ![]()
In this study, we compared the kinetics of the postirradiation p53 protein expression for carbon ion beam (290 MeV/n, LET 75 keV/mu m) and proton beam (65 MeV) with that of (13)7Cs-gamma ray. We used two human lymphoblastoid cell lines derived from the same donor with different p53 status. Wild-type p53 protein increased after irradiation and it was dose-dependent. Meanwhile, the mutated p53 protein level did not show any increase with irradiation. With the three forms of radiation, there was no significant difference as regards the p53 protein kinetics. |
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